Table 3

Experimental Studies Illustrating the Potential for Additive Cardioprotection With Multiple Cardioprotective Agents or Interventions Targeting Distinct Time-Points During Ischemia and Reperfusion

First Author, Year (Ref. #)Experimental AMI ModelCardioprotective Agents or InterventionsCardioprotective EffectTiming of Intervention
Xin et al., 2010 (62)In vivo ratLimb RIPerC (4 × 5/5-min cycles)
IPost (6 × 10/10-s cycles)
Additive effects on reducing MI size, reducing ROS at reperfusion and inhibiting apoptosisIschemia—limb RIPerC
Reperfusion—IPost
Additive effects on Akt and Erk1/2 phosphorylation
Yang et al., 2013 (44)In vivo ratCangrelor at reperfusion
Hypothermia (32°C–33°C) during ischemia
Cariporide during ischemia
Additive effects of cangrelor combined with either cariporide or hypothermia on reducing MI size. Additive protection with all 3Reperfusion—cangrelor, P2Y12 inhibitor
Ischemia—hypothermia, reduces energy consumption
Ischemia—cariporide, Na+/H+ exchanger inhibitor

IPost = post-conditioning; ROS = reactive oxygen species; other abbreviations as in Table 1.

  • Other criteria are as per Table 1.