Table 4

Analysis of Repeat Hospitalizations in Men and Women With HFrEF (Negative Binomial Model)

Total EventsEvents per 100 Person-Years (95% CI)Women vs. Men
Women (n = 3,357)Men (n = 12,058)Women (n = 3,357)Men (n = 12,058)Unadjusted IRR (95% CI) p ValueAdjusted IRR (95% CI) p Value
HF hospitalization7503,5698.48 (7.89–9.11)11.40 (11.04–11.79)0.70 (0.62–0.80)
<0.001
0.69 (0.61–0.79)
<0.001
CV hospitalization1,7198,01719.44 (18.54–20.38)25.62 (25.07–26.19)0.74 (0.68–0.81)
<0.001
0.73 (0.67–0.79)
<0.001
Non-CV hospitalization1,2875,62414.55 (13.78–15.37)17.98 (17.51–18.45)0.87 (0.80–0.95)
0.001
0.82 (0.75–0.89)
<0.001
All-cause hospitalization3,00613,64133.99 (32.79–35.22)43.60 (42.87–44.34)0.79 (0.74–0.84)
<0.001
0.75 (0.70–0.81)
<0.001

Values are n, unless otherwise indicated. Incident rate ratios (IRRs) adjusted for age, previous HF hospitalization, heart rate, systolic blood pressure, NT-proBNP, BMI, NYHA functional class, LVEF, and eGFR.

Abbreviations as in Table 2 and 3.