Table 3

Association of Multiple Fat Depots With Incident CVD (40 Events in Women, 50 Events in Men) and Incident Cancer (68 Events in Women, 73 Events in Men) Stratified by Sex

Adiposity MeasureWomen
(n = 1,519)
Men
(n = 1,567)
p Value for Interaction
Age-Adjusted ModelMultivariable ModelAge-Adjusted ModelMultivariable Model
Incident CVD
 VAT1.20 (0.90–1.59)1.04 (0.65–1.65)1.64 (1.27–2.11)1.66 (1.16–2.39)0.1
 Periaortic fat1.19 (0.91–1.56)1.08 (0.75–1.55)1.47 (1.16–1.85)1.37 (1.02–1.84)0.5
 Pericardial fat1.13 (0.85–1.49)0.97 (0.69–1.36)1.28 (1.05–1.55)1.16 (0.91–1.47)0.4
 SAT1.24 (0.90–1.71)1.33 (0.72–2.45)1.22 (0.93–1.61)0.79 (0.47–1.33)1.0
Incident cancer
 VAT1.19 (0.94–1.49)1.27 (0.88–1.82)1.20 (0.96–1.49)1.43 (1.06–1.94)0.4
 Periaortic fat1.28 (1.02–1.62)1.31 (0.97–1.77)1.11 (0.90–1.38)1.13 (0.86–1.49)1.0
 Pericardial fat1.06 (0.83–1.35)0.96 (0.72–1.29)1.25 (1.05–1.48)1.24 (1.02–1.51)0.06
 SAT1.00 (0.78–1.28)0.80 (0.49–1.30)0.98 (0.76–1.27)0.99 (0.64–1.54)0.9
All-cause death
 VAT1.12 (0.77–1.62)1.18 (0.66–2.14)1.27 (0.99–1.62)0.92 (0.65–1.28)0.3
 Periaortic fat1.06 (0.72–1.55)1.05 (0.64–1.71)1.28 (1.04–1.58)0.95 (0.72–1.24)0.2
 Pericardial fat1.11 (0.77–1.60)1.09 (0.73–1.64)1.36 (1.12–1.65)1.16 (0.91–1.46)0.2
 SAT0.84 (0.54–1.32)0.73 (0.32–1.63)1.26 (0.91–1.74)0.74 (0.41–1.33)0.2

Values are HR (95% CI).

Abbreviations as in Tables 1 and 2.

  • Adjusted for age, systolic blood pressure, diabetes, total cholesterol, high-density lipoprotein cholesterol, current smoking, hypertension treatment, and body mass index.

  • p interaction is age adjusted.