Table 1

Prevalence of Plaque Hemorrhage and Annualized Event Rates

First Author/Year (Ref. #)RegionSample TypeNMean Age (yrs)Men (%)History of CAD / Ischemic Heart Disease / Diabetes / Smoker / Hypertension / Hyperlipidemia / Statins (%) / Antiplatelets (%)MRI Scanner
(T)
Exclusion After Enrollment
Teng et al. 2011 (20)Europe, U.K.TIA, MRI scan within 72 h after symptoms4273.46016.7 / not stated / 9.5 / not stated / 73.8 / not stated / 59.5 / 361.50
Kurosaki et al. 2011 (14)Asia, JapanTIA, stroke according to TOAST criteria6277.881Not stated / 58.1 / 41.9 / not stated / 67.7 / 29.0 / 21.0 / 85.51.50
Sadat et al. 2010 (21)Europe, U.K.TIA or minor, nondisabling stroke diagnosed by a consultant stroke physician6174.0Not stated14.8 / 34.4 / 9.8 / not stated / 80.3 / not stated / 100 / 1001.50
Kume et al. 2010 (12)Asia, JapanCarotid plaque and >50% stenosis by US16570.981Not stated / 29.7 / 46.0 / 34.0 / 67.3 / 43.0 / 14.6 / 57.01.50
Singh et al. 2009 (15)North America, CanadaModerate asymptomatic stenosis 50%–70%7574.9100Not stated / not stated / 17.3 / 78.7 / 74.7 / 72.0 / 70.7 / 78.71.51
Altaf et al. 2007 (22)Europe, U.K.Symptomatic patients with 60% to 99% stenosis6670.070Not stated / 31.8 / 9.1 / 65.2 / 78.8 / not stated / 90.1 / 95.51.510
Altaf et al. 2008 (13)Europe, U.K.Symptomatic patients with mild to moderate carotid stenosis (30%–69%)6472.780Not stated / 15.6 / 20.3 / 70.3 / 78.1 / not stated / 75.0 / 98.41.59
Takaya et al. 2006 (16)North America, U.S.Asymptomatic, 50%–79% stenosis15471.18244 / not stated / 25 / 38 / 75 / 79 / 64 / not stated1.529

CAD = coronary artery disease; MRI = magnetic resonance imaging; TIA = transient ischemic attack; TOAST = Trial of Org 10172 in Acute Stroke Treatment; US = ultrasound.

  • Median age.