Table 1

Baseline Characteristics of CRT Responders and Nonresponders

All
(N = 75)
Responders
(n = 40)
Nonresponders
(n = 35)
p Value
Demographic/clinical
 Age, yrs65.9 (57.8–74.3)65.3 (57.7–72.6)67.9 (59.2–76.4)0.35
 Female19 (25.3)16 (40.0)3 (8.6)0.003
 NYHA functional class II/III/IV3 (4.0)/71 (94.7)/1 (1.3)3 (7.5)/37 (92.5)/0 (0)0 (0)/34 (97.1)/1 (2.9)0.17
CMR imaging parameters
 LVEF, %23.2 (15.0–28.4)22.8 (16.1–27.9)23.2 (13.8–28.4)0.81
 LVEDV index, ml122 (104.1–151.0)110.0 (91.4–139.3)133.7 (110.5–155.6)0.007
 LVESV index, ml96.9 (78.0–126.4)88.0 (71.6–116.1)109.3 (86.8–136.6)0.02
 SV index, ml26.8 (21.2–33.9)26.1 (21.0–28.0)31.0 (24.0–38.0)0.03
 LV mass index, g/m270.9 (59.4–82.9)63.6 (49.5–80.7)74.6 (66.0–90.2)0.006
 LGE present41 (54.7)17 (42.5)24 (68.6)0.04
 LV scar volume, %4.3 (0–12.7)0 (0–12.3)7.3 (0–12.9)0.12
 CURE0.61 (0.36–0.74)0.37 (0.26–0.61)0.75 (0.64–0.81)<0.0001
Electrical, mechanical, and scar properties at LV lead
 QLV108 (72–140)125 (107–143)90 (60–105)0.0002
 Lead position in scar28 (37.3)8 (20.0)20 (57.1)0.002
 Initial mechanical stretch43 (57.3)29 (72.5)14 (40)0.006
ECG parameters
 QRS duration, ms155 (140–170)160 (150–172)150 (134–170)0.12
 LBBB67 (89.3)39 (97.5)28 (80.0)0.02
Comorbid conditions
 Prior MI34 (45.3)14 (35.0)20 (57.1)0.06
 Prior CABG9 (12.0)4 (10.0)5 (14.3)0.72
 Chronic kidney disease15 (20.0)10 (25.0)5 (14.3)0.38
 Diabetes mellitus21 (28.0)9 (22.5)11 (34.3)0.30
 Peripheral arterial disease9 (12.0)3 (7.5)6 (17.1)0.28
 Hypertension41 (54.7)24 (60.0)17 (48.6)0.36
 Prior stroke/TIA7 (9.3)5 (12.5)2 (5.7)0.43
 Obstructive sleep apnea15 (20.0)7 (17.5)8 (22.9)0.58
Events during follow-up
 Death16 (21.3)2 (5.0)14 (40.0)0.0004
 Sustained VT12 (16.0)2 (5.0)10 (28.6)0.01
 HF hospitalization20 (26.7)3 (7.5)17 (48.6)<0.0001

Values are median (interquartile range) or n (%). The numbers in parentheses for New York Heart Association (NYHA) functional class are the percentages of patients in each class.

CABG = coronary artery bypass graft; CMR = cardiac magnetic resonance; CRT = cardiac resynchronization therapy; CURE = circumferential uniformity ratio estimate; ECG = electrocardiogram; LBBB = left bundle branch block; LGE = late gadolinium enhancement; LV = left ventricle/ventricular; LVEDV = left ventricular end-diastolic volume; LVEF = left ventricular ejection fraction; LVESV = left ventricular end-systolic volume; MI = myocardial infarction; QLV = QRS to left ventricular electrogram interval; SV = stroke volume; TIA = transient ischemic attack; VT = ventricular tachyarrhythmia.