Table 2

Multivariate Cox Regression Analyses for All-Cause and Cardiovascular Mortality at 5 Years

All-Cause DeathCardiovascular Death
Gal-3ST2Gal-3ST2
HR95% CIp ValueHR95% CIp ValueHR95% CIp ValueHR95% CIp Value
Age, yrs1.041.03–1.06<0.0011.041.03–1.05<0.0011.041.03–1.06<0.0011.041.02–1.06<0.001
Female0.670.52–0.870.0030.740.57–0.960.0260.650.46–0.940.0210.700.48–1.000.052
NYHA functional class1.701.34–2.15<0.0011.641.29–2.08<0.0011.781.30–2.40<0.0011.831.34–2.50<0.001
LVEF1.001.00–1.010.3201.011.00–1.010.3161.011.00–1.020.2291.011.00–1.020.199
Ischemic etiology of HF1.120.88–1.410.3571.140.9–1.450.2651.340.97–1.840.0741.320.96–1.810.092
Diabetes mellitus1.170.93–1.460.1791.160.93–1.450.1871.280.95–1.70.1021.250.93–1.690.143
eGFR, ml/min/1.73 m21.001.00–1.010.9271.000.99–1.000.2451.000.99–1.010.6501.000.99–1.010.464
Na, mmol/l0.970.94–1.000.0650.980.95–1.010.2240.930.90–0.970.0010.930.89–0.97<0.001
Hb, g/dl0.930.87–1.000.0490.920.86–0.980.0141.020.93–1.120.6921.000.92–1.100.942
ACEI or ARB treatment0.810.59–1.110.1810.880.63–1.220.4440.780.51–1.180.2430.720.47–1.100.133
Beta-blocker treatment0.520.39–0.69<0.0010.530.40–0.72<0.0010.480.32–0.72<0.0010.490.33–0.72<0.001
Log(NT-proBNP)1.121.15–1.41<0.0011.231.10–1.36<0.0011.291.13–1.48<0.0011.291.12–1.48<0.001
Log(Gal-3)1.371.03–1.830.0321.350.92–1.980.127
ST21.231.12–1.36<0.0011.271.05–1.530.014

New York Heart Association as functional classes III to IV. The logarithmic functions of NT-proBNP and Gal-3 and the quadratic term of ST2 were used in the Cox models. ST2 per every 10 ng/ml change. The p value for ST22 = 0.001 for all-cause mortality and 0.024 for cardiovascular mortality. Dashes indicate non applicable.

CI = confidence interval; Gal-3 = galectin-3; Hb = hemoglobin; HF = heart failure; HR = hazard ratio; other abbreviations as in Table 1.