Table 2

Hazard Ratios (95% CI) for Primary and Secondary MACE Endpoints Associated With CAC and cPB

No AtherosclerosisTertile 1Tertile 2Tertile 3p Value (Trend)
Hazard ratios (95% CI) for primary MACE endpoint
 cPB
 Model 11.0 (ref)0.87 (0.36–2.10)1.56 (0.72–3.36)2.85 (1.39–5.82)<0.001
 Model 21.0 (ref)0.78 (0.31–1.91)1.45 (0.67–3.14)2.36 (1.13–4.92)0.03
 CAC
 Model 11.0 (ref)1.13 (0.52–2.50)1.54 (0.74–3.22)3.15 (1.60–6.21)<0.001
 Model 21.0 (ref)1.11 (0.49–2.53)1.58 (0.74–3.38)2.99 (1.48–6.05)0.01
Hazard ratios (95% CI) for secondary MACE endpoint
 cPB
 Model 11.0 (ref)1.59 (0.92–2.74)2.27 (1.36–3.79)3.41 (2.08–5.58)<0.001
 Model 21.0 (ref)1.53 (0.89–2.65)2.14 (1.28–3.59)2.87 (1.73–4.74)0.001
 CAC
 Model 11.0 (ref)1.47 (0.91–2.36)1.66 (1.04–2.64)3.32 (2.16–5.10)<0.001
 Model 21.0 (ref)1.39 (0.85–2.25)1.54 (0.96–2.47)2.97 (1.92–4.60)<0.001

Model 1 was adjusted for age, race, and sex. Model 2 was additionally adjusted for: diabetes mellitus; current smoking; body mass index; systolic blood pressure; antihypertensive agent use; low-density lipoprotein cholesterol; high-density lipoprotein cholesterol; and use of lipid-lowering drugs.

CAC = coronary artery calcium; CI = confidence interval; cPB = carotid plaque burden; CVD = cardiovascular; MACE = major adverse cardiovascular event(s).