Table 1

Baseline Characteristics

hs-cTnTp Value
<6 ng/l
(n = 5,790)
6–13 ng/l
(n = 6,491)
14–49 ng/l
(n = 10,476)
≥50 ng/l
(n = 25,837)
Age, yrs58 (48–66)66 (58–74)73 (64–81)72 (63–81)<0.001
Male2,991 (51.7)3,976 (61.3)6,671 (63.7)16,774 (64.9)<0.001
Risk factors
 Smoking1,167 (20.2)967 (14.9)1,331 (12.7)4,923 (19.1)<0.001
 Diabetes mellitus693 (12)1,211 (18.7)2,680 (25.7)6,050 (23.5)<0.001
 Hypertension2,131 (36.9)3,322 (51.3)5,948 (57)13,238 (51.3)<0.001
Previous cardiovascular disease
 Myocardial infarction1,250 (21.7)2,226 (34.4)4,227 (40.5)8,038 (31.2)<0.001
 Heart failure272 (4.7)658 (10.2)1,830 (17.5)3,437 (13.3)<0.001
 Stroke244 (4.2)476 (7.4)1,094 (10.5)2,647 (10.3)<0.001
 PCI1,194 (20.7)2,019 (31.2)3,058 (29.3)4,623 (17.9)<0.001
 CABG308 (5.3)740 (11.4)1,696 (16.2)2,924 (11.3)<0.001
Medication on admission
 Aspirin2,141 (37.1)3,315 (51.2)5,451 (52.2)10,949 (42.5)<0.001
 P2Y12 receptor blocker536 (9.3)953 (14.7)1,526 (14.6)2,615 (10.1)<0.001
 Beta-blocker2,192 (38)3,397 (52.5)5,861 (56.2)11,083 (43)<0.001
 Statin2,069 (35.9)3,163 (48.9)5,126 (49.1)9,235 (35.8)<0.001
 ACEI/ARB1,747 (30.3)2,957 (45.7)5,350 (51.3)10,298 (39.9)<0.001
Cardiogenic shock at admission7 (0.1)18 (0.3)39 (0.4)284 (1.1)<0.001
Main reason for presentation
 Chest pain5,020 (87)5,591 (86.8)8,046 (77.5)20,307 (79.1)<0.001
 Dyspnea167 (2.9)231 (3.6)1,091 (10.5)2,565 (10.0)<0.001
 Cardiac arrest8 (0.1)15 (0.2)40 (0.4)466 (1.8)<0.001
 Other574 (9.9)603 (9.4)1,200 (11.6)2,333 (9.1)<0.001
Electrocardiography
 Sinus rhythm5,315 (92.1)5,582 (86.6)7,870 (75.7)21,274 (82.8)<0.001
 Atrial fibrillation/flutter350 (6.1)670 (10.4)1,914 (18.4)3,322 (12.9)<0.001
 ST-segment depression582 (10.1)714 (11.1)1,676 (16.2)5,902 (23)<0.001
 ST-segment elevation302 (5.3)355 (5.5)564 (5.4)7,328 (28.5)<0.001
Systolic blood pressure, mm Hg145 (130–160)149 (131–165)149 (130–167)145 (125–165)<0.001
Diastolic blood pressure, mm Hg82 (75–92)82 (73–91)80 (70–90)82 (70–95)<0.001
Heart rate, beats/min74 (64–86)72 (63–85)76 (65–92)80 (68–97)<0.001
GFR, ml/min91.3 (78.7–101.4)82.7 (68.5–93.3)70.7 (53.6–85.9)71.2 (50.5–87.7)<0.001

Values are median (interquartile range) or n (%), unless otherwise indicated.

ACEI = angiotensin-converting enzyme inhibitor; ARB = angiotensin receptor blocker; CABG = coronary artery bypass grafting; GFR = glomerular filtration rate; hs-cTnT = high-sensitivity cardiac troponin T; PCI = percutaneous coronary intervention.

  • Include symptoms suggestive of possible acute coronary syndrome other than chest pain and dyspnea, such as nausea, abdominal discomfort, and general malaise.