Table 3

Association Between Metabolic Syndrome and Systolic and Diastolic Echocardiographic Abnormalities in Adult Survivors of Childhood Cancer

3D LVEF < 50%Abnormal Global Longitudinal StrainAbnormal Global Circumferential StrainDiastolic Grade 1–3Abnormal Lateral e′Abnormal Left Atrial Volume
RR95% CIRR95% CIRR95% CIRR95% CIRR95% CIRR95% CI
Metabolic syndrome
 Yes1.070.74–1.531.941.66–2.281.020.84–1.241.681.39–2.031.651.35–2.021.411.14–1.74
 No1.001.001.001.001.001.00
Abdominal obesity
 Yes1.340.99–1.821.731.48–2.011.100.92–1.321.691.39–2.061.491.23–1.821.831.53–2.19
 No1.001.001.001.001.001.00
Triglycerides ≥ 150 mg/dl
 Yes1.010.70–1.441.651.40–1.951.010.82–1.231.441.17–1.781.351.07–1.701.030.79–1.33
 No1.001.001.001.001.001.00
Low HDL cholesterol
 Yes1.010.74–1.381.401.23–1.590.920.78–1.081.361.14–1.621.200.97–1.471.200.98–1.47
 No1.001.001.001.001.001.00
Hypertension
 Yes1.441.22–1.701.481.33–1.651.040.92–1.181.391.22–1.581.341.17–1.551.301.13–1.49
 No1.001.0011.001.001.00
Fasting glucose ≥100 mg/dl
 Yes1.020.75–1.391.371.19–1.591.060.89–1.251.421.18–1.701.471.22–1.771.000.81–1.25
 No1.001.001.001.001.001.00

Values in bold are statistically significant.

Abbreviations as in Tables 1 and 2.

  • Adjusted for current age, age at diagnosis, race/ethnicity, sex, chest RT, and anthracycline exposure.