Table 2

Multivariate Associations Between Treatment Characteristics and Systolic and Diastolic Dysfunction in Adult Survivors of Childhood Cancer

3D LVEF < 50%Abnormal Global Longitudinal StrainAbnormal Global Circumferential StrainDiastolic Grade 1–3Abnormal Lateral e′Abnormal Left Atrial Volume
RR95% CIRR95% CIRR95% CIRR95% CIRR95% CIRR95% CI
Race/ethnicity
 Other1.530.93–2.521.221.03–1.460.840.64–1.091.240.86–1.781.320.89–1.962.031.41–2.93
 Non-Hispanic white1.001.001.001.001.00
Sex
 Female0.540.36–0.831.551.34–1.791.010.84–1.211.150.88–1.510.980.73–1.320.600.43–0.83
 Male1.001.001.001.001.001.00
Age at diagnosis, yrs
 0–40.660.35–1.271.020.82–1.271.240.92–1.670.850.56–1.290.910.58–1.441.260.79–2.01
 5–90.670.36–1.250.920.74–1.151.010.74–1.380.810.53–1.220.800.50–1.261.230.74–2.05
 10–141.020.59–1.761.020.83–1.241.110.84–1.480.870.61–1.230.770.50–1.171.180.74–1.86
 ≥151.001.001.001.001.001.00
Current age, yrs
 31–401.380.81–2.351.251.05–1.480.850.69–1.062.431.59–3.711.961.31–2.932.401.67–3.45
 >400.980.52–1.841.491.20–1.850.980.73–1.334.742.90–7.751.520.90–2.543.592.25–5.73
 18–301.001.001.001.001.001.00
Anthracycline cumulative dose, mg/m2
 1–1001.740.66–4.611.381.05–1.820.990.66–1.480.750.43–1.300.620.29–1.322.070.95–4.51
 101–2002.801.24–6.311.160.89–1.501.240.86–1.790.800.51–1.251.130.65–1.971.820.85–3.91
 201–3003.801.59–9.101.060.78–1.451.360.90–2.040.760.42–1.371.770.99–3.151.340.55–3.25
 301–4004.762.16–10.501.721.31–2.261.611.08–2.401.000.59–1.691.530.84 2.811.720.73–4.05
 >4007.713.04–19.571.731.19–2.501.340.78–2.311.330.72–2.452.050.99–4.240.950.30–2.99
 None1.001.001.001.001.001.00
Chest RT cumulative dose (Gy)
 1–19.91.240.70–2.221.381.14–1.660.860.66–1.111.470.99–2.201.090.69–1.720.470.29–0.78
 20–29.91.861.00–3.451.651.31–2.081.140.83–1.572.031.30–3.172.011.27–3.211.100.65–1.87
 ≥307.993.88–16.482.391.79–3.181.641.05–2.562.441.44–4.144.032.22–7.320.630.21–1.89
 None1.001.001.001.001.001.00

Values in bold are statistically significant.

CI = confidence interval; LVEF = left ventricular ejection fraction; RR = rate ratio; RT = radiotherapy; 3D = 3-dimensional.