Table 4

Unadjusted and Adjusted Odds Ratios for the Association of the Primary and Secondary Endpoints With Radiation Therapy

UnadjustedAdjusted
OR (95% CI)p ValueOR (95% CI)p Value
Primary endpoints
 Elevated resting heart rate3.68 (2.65–5.12)<0.00013.96 (2.52–6.22)<0.0001
 Abnormal heart rate recovery at 1 min4.57 (3.09–6.76)<0.00015.32 (2.94–9.66)<0.0001
Secondary endpoints
 Heart rate reserve (lowest tertile)2.15 (1.57–2.93)<0.00013.20 (1.64–6.27)0.0007
 Chronotropic incompetence0.95 (0.65–1.39)0.851.57 (0.87–2.84)0.14
 Abnormal systolic BP response1.88 (1.25–2.81)0.0031.44 (0.76–2.71)0.26
 Abnormal reserve pulse pressure1.45 (1.08–1.96)0.021.41 (0.90–2.23)0.14

AVN = atrioventricular nodal; BP = blood pressure; ETT = exercise treadmill test; IHD = ischemic heart disease.

  • Adjusted for age, sex, Morise risk score, diabetes, indication for ETT, AVN-blocking medications, congestive heart failure/IHD, and anthracycline exposure.

  • Adjusted for age, sex, Morise risk score, diabetes, indication for ETT, AVN-blocking medications, congestive heart failure/IHD, resting HR, exercise time, result of ETT, and anthracycline exposure.

  • Adjusted for age, sex, Morise risk score, diabetes, indication for ETT, antihypertensive medications, congestive heart failure/IHD, resting HR, exercise time, result of ETT, and anthracycline exposure.