Table 3

Heart Rate and Blood Pressure Responses to Matched Levels of Exercise for Radiation and Control Cohorts

Radiation Patients
(n = 263)
Control Patients
(n = 526)
p Value
Primary endpoints
 Elevated resting heart rate
 Heart rate at rest, beats/min78 ± 1268 ± 12<0.0001
 Elevated heart rate at rest, ≥80 beats/min117 (44.5)94 (17.9)<0.0001
 Abnormal heart rate recovery
 Heart rate recovery at 1 min, beats/min23 ± 1333 ± 14<0.0001
 Abnormal heart rate recovery at 1 min84 (31.9)49 (9.3)<0.0001
Secondary endpoints
 Heart rate response to exercise
 Heart rate reserve, beats/min81 ± 2590 ± 23<0.0001
 Chronotropic incompetence49 (18.6)102 (19.4)0.85
 Blood pressure response to exercise
 Abnormal systolic blood pressure response52 (19.8)61 (11.6)0.003
 Abnormal reserve pulse pressure146 (55.5)243 (46.2)0.017

Values are mean ± SD or n (%).