Table 2

Clinical Characteristics and Outcomes of Patients According to ICD Indication

Overall
(n = 176)
Aborted SCD
(n = 25)
Syncope
(n = 105)
Asymptomatic
(n = 46)
p Value
Clinical features
 Age, yrs43.3 ± 16.839.5 ± 15.643.2 ± 17.245.3 ± 16.60.41
 Male118 (67.0)16 (64.0)66 (62.9)36 (78.3)0.17
 Proband92 (52.3)16 (64.0)57 (54.3)19 (41.3)0.15
 Spontaneous type 1 ECG pattern37 (21.0)7 (28.0)19 (18.1)11 (23.9)0.47
 Family history of SCD90 (51.1)10 (40.0)53 (50.5)27 (58.7)0.32
 Previous atrial arrhythmias24 (13.6)3 (12.0)14 (13.3)7 (15.2)0.92
 Previous SND9 (5.1)1 (4.0)5 (4.8)3 (6.5)0.87
 Inducible on EPS72 (43.6)5 (26.3)39 (37.9)28 (65.1)<0.01
 SCN5A mutations23 (21.9)6 (26.1)9 (15.8)8 (32)0.23
Outcomes
 Appropriate shocks28 (15.9)11 (44.0)11 (10.5)6 (13.0)<0.01
 Time to first therapy, months20.7 ± 25.923.6 ± 32.519.9 ± 18.515.7 ± 28.30.85
 Shock rate per year0.46 ± 1.050.23 ± 0.280.8 ± 1.560.16 ± 0.110.38
 Inappropriate shocks33 (18.8)8 (32.0)18 (17.1)7 (15.2)0.54
 Time to first therapy (months)49.9 ± 46.253.9 ± 47.654.8 ± 50.434.2 ± 36.80.66
 Shock rate per year0.47 ± 1.260.19 ± 0.190.64 ± 1.590.17 ± 0.050.71
 Deaths8 (4.5)3 (12.0)5 (4.8)0 (0)0.10

Values are mean ± SD or n (%).

Abbreviations as in Table 1.

  • Percents refer to patients who underwent EPS and genetic testing.