Table 2

Patient Characteristics Across Treatment Strategies

Combined Dataset (N = 2,303)
Device Closure
(n = 1,150)
Medical Therapy
(n = 1,153)
Source data
 CLOSURE38.9 (447)40.1 (462)
 PC trial17.7 (204)18.2 (210)
 RESPECT43.4 (499)41.7 (481)
Clinical variables
 Age45.3 ± 9.8 (1,143)45.3 ± 9.7 (1,148)
 Male51.6 (593/1,150)53.8 (620/1,153)
 Body mass index28.0 ± 5.6 (654)27.8 ± 5.8 (651)
 Current smoker17.0 (196/1,150)14.9 (171/1,151)
Medical history
 Coronary artery disease3.1 (36/1,150)1.7 (20/1,153)
 Diabetes6.9 (79/1,150)6.6 (76/1,153)
 Hypercholesterolemia39.7 (456/1,150)38.5 (444/1,153)
 Hypertension31.1 (358/1,150)29.4 (339/1,153)
 Migraine34.3 (394/1,150)32.6 (376/1,153)
 Prior stroke/TIA19.5 (224/1,150)19.7 (227/1,153)
Echocardiographic variables
 Hypermobile septum33.6 (380/1,130)33.2 (378/1,137)
 Large PFO63.2 (672/1,063)58.9 (620/1,052)
Index event variables
 Index event of stroke89.4 (1,027/1,149)88.5 (1,020/1,152)
 Superficial stroke55.8 (484/867)57.2 (511/894)
 Baseline NIHSS0.7 ± 1.6 (942)0.7 ± 1.4 (940)
 Baseline Rankin0.7 ± 0.8 (941)0.6 ± 0.8 (941)

Values are % (n), mean ± SD (n), or % (n/N) of patients with available data.

Abbreviations as in Table 1.

  • Findings on transesophageal echocardiography.