Characteristics of Acute Vasodilator Responders Versus Nonresponders
| IPAH/FPAH (n = 212) | Responder According to: | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Physician’s Judgment | p Value | REVEAL-Pediatric Criteria | p Value | Sitbon Criteria | p Value | ||||
| Yes | No | Yes | No | Yes | No | ||||
| Age at diagnosis, yrs | 7.1 (4.2–12.1) | 8.1 (4.2–13.4) | 0.187 | 7.3 (4.2–13.0) | 8.0 (4.3–13.1) | 0.789 | 8.5 (4.7–12.8) | 7.4 (4.0–13.2) | 0.731 |
| Female | 53 (67.9) | 80 (59.7) | 0.231 | 47 (75.8) | 81 (56.6) | 0.009 | 28 (87.5) | 105 (58.3) | 0.002 |
| Incident patients | 33 (42.3) | 73 (54.5) | 0.087 | 35 (56.5) | 67 (46.9) | 0.207 | 17 (53.1) | 89 (49.4) | 0.701 |
| WHO functional class | |||||||||
| I | 13 (16.7) | 15 (11.2) | 0.314 | 7 (11.3) | 20 (14.0) | 0.407 | 2 (6.3) | 26 (14.4) | 0.620 |
| II | 36 (46.2) | 53 (39.6) | 27 (43.5) | 58 (40.6) | 17 (53.1) | 72 (40.0) | |||
| III | 16 (20.5) | 57 (42.5) | 16 (25.8) | 55 (38.5) | 7 (21.9) | 66 (36.7) | |||
| IV | 13 (16.7) | 9 (6.7) | 12 (19.4) | 10 (7.0) | 6 (18.8) | 16 (8.9) | |||
| Sedation method at HC | |||||||||
| General anesthesia | 29 (28.7) | 72 (71.3) | 0.017 | 23 (24.2) | 72 (75.8) | 0.097 | 8 (7.9) | 93 (92.1) | 0.005 |
| Procedural sedation | 49 (44.5) | 61 (55.5) | 38 (34.9) | 71 (65.1) | 24 (21.8) | 86 (78.2) | |||
| Baseline mPAP, mm Hg | 56 ± 16 | 62 ± 19 | 0.018 | 54 ± 16 | 62 ± 19 | 0.002 | 49 ± 13 | 61 ± 18 | <0.001 |
| AVT mPAP, mm Hg | 37 ± 17 | 56 ± 19 | <0.001 | 33 ± 12 | 56 ± 19 | <0.001 | 27 ± 8 | 53 ± 19 | <0.001 |
| Baseline mRAP, mm Hg | 6 ± 3 | 8 ± 4 | 0.001 | 6 ± 4 | 7 ± 4 | 0.002 | 5 ± 3 | 7 ± 4 | <0.001 |
| AVT mRAP, mm Hg | 6 ± 3 | 8 ± 4 | 0.002 | 6 ± 3 | 8 ± 4 | <0.001 | 5 ± 3 | 7 ± 4 | <0.001 |
| Baseline PVRi, WU·m2 | 13.5 (8.6–19.5) | 17.3 (11.3–24.2) | 0.007 | 12.7 (7.9–18.9) | 16.7 (12.1–24.2) | 0.002 | 12.9 (8.0–18.5) | 16.3 (10.9–23.9) | 0.006 |
| AVT PVRi | 6.0 (4.0–10.6) | 15.2 (8.7–22.4) | <0.001 | 4.5 (3.6–9.1) | 14.8 (8.7–22.3) | <0.001 | 4.2 (3.1–5.9) | 12.6 (7.4–20.0) | <0.001 |
| Baseline cardiac index, l/min/m2 | 3.3 (2.8–4.3) | 2.9 (2.2–3.8) | 0.018 | 3.2 (2.7–4.4) | 2.9 (2.4–4.0) | 0.082 | 3.2 (2.8–4.4) | 3.0 (2.4–4.0) | 0.251 |
| AVT cardiac index, l/min/m2 | 3.6 (2.9–4.5) | 3.1 (2.3–4.1) | 0.003 | 3.8 (3.0–5.0) | 3.1 (2.3–3.9) | <0.001 | 4.2 (3.4–5.1) | 3.1 (2.4–4.0) | <0.001 |
| Baseline PVRi/SVRi | 0.8 (0.6–0.9) | 0.9 (0.7–1.2) | 0.004 | 0.7 (0.5–0.9) | 0.9 (0.7–1.1) | 0.001 | 0.7 (0.5–0.8) | 0.9 (0.7–1.1) | <0.001 |
| AVT PVRi/SVRi | 0.4 (0.2–0.6) | 0.7 (0.5–1.0) | <0.001 | 0.4 (0.2–0.5) | 0.7 (0.5–1.0) | <0.001 | 0.3 (0.2–0.4) | 0.7 (0.4–1.0) | <0.001 |
| Baseline mPAP/mSAP | 0.8 (0.6–1.0) | 0.9 (0.7–1.1) | 0.007 | 0.8 (0.6–1.0) | 0.9 (0.7–1.1) | 0.004 | 0.7 (0.6–0.9) | 0.9 (0.7–1.1) | <0.001 |
| AVT mPAP/mSAP | 0.5 (0.3–0.7) | 0.8 (0.6–1.0) | <0.001 | 0.4 (0.3–0.6) | 0.8 (0.6–1.0) | <0.001 | 0.4 (0.3–0.5) | 0.7 (0.5–1.0) | <0.001 |
| AVT agent | |||||||||
| iNO (and O2) | 50 (64.1) | 102 (76.1) | 0.061 | 47 (75.8) | 102 (71.3) | 0.509 | 23 (71.9) | 129 (71.7) | 0.981 |
| Other | 28 (35.9) | 32 (23.9) | 15 (24.2) | 41 (28.7) | 9 (28.1) | 51 (28.3) | |||
Values are median (interquartile range), n (%), or mean ± SD.
mSAP = mean systemic arterial pressure; SVRi = systemic vascular resistance index; other abbreviations as in Tables 1 and 2.