Table 4

Characteristics of Acute Vasodilator Responders Versus Nonresponders

IPAH/FPAH (n = 212)Responder According to:
Physician’s Judgmentp ValueREVEAL-Pediatric Criteriap ValueSitbon Criteriap Value
YesNoYesNoYesNo
Age at diagnosis, yrs7.1 (4.2–12.1)8.1 (4.2–13.4)0.1877.3 (4.2–13.0)8.0 (4.3–13.1)0.7898.5 (4.7–12.8)7.4 (4.0–13.2)0.731
Female53 (67.9)80 (59.7)0.23147 (75.8)81 (56.6)0.00928 (87.5)105 (58.3)0.002
Incident patients33 (42.3)73 (54.5)0.08735 (56.5)67 (46.9)0.20717 (53.1)89 (49.4)0.701
WHO functional class
 I13 (16.7)15 (11.2)0.3147 (11.3)20 (14.0)0.4072 (6.3)26 (14.4)0.620
 II36 (46.2)53 (39.6)27 (43.5)58 (40.6)17 (53.1)72 (40.0)
 III16 (20.5)57 (42.5)16 (25.8)55 (38.5)7 (21.9)66 (36.7)
 IV13 (16.7)9 (6.7)12 (19.4)10 (7.0)6 (18.8)16 (8.9)
Sedation method at HC
 General anesthesia29 (28.7)72 (71.3)0.01723 (24.2)72 (75.8)0.0978 (7.9)93 (92.1)0.005
 Procedural sedation49 (44.5)61 (55.5)38 (34.9)71 (65.1)24 (21.8)86 (78.2)
Baseline mPAP, mm Hg56 ± 1662 ± 190.01854 ± 1662 ± 190.00249 ± 1361 ± 18<0.001
AVT mPAP, mm Hg37 ± 1756 ± 19<0.00133 ± 1256 ± 19<0.00127 ± 853 ± 19<0.001
Baseline mRAP, mm Hg6 ± 38 ± 40.0016 ± 47 ± 40.0025 ± 37 ± 4<0.001
AVT mRAP, mm Hg6 ± 38 ± 40.0026 ± 38 ± 4<0.0015 ± 37 ± 4<0.001
Baseline PVRi, WU·m213.5 (8.6–19.5)17.3 (11.3–24.2)0.00712.7 (7.9–18.9)16.7 (12.1–24.2)0.00212.9 (8.0–18.5)16.3 (10.9–23.9)0.006
AVT PVRi6.0 (4.0–10.6)15.2 (8.7–22.4)<0.0014.5 (3.6–9.1)14.8 (8.7–22.3)<0.0014.2 (3.1–5.9)12.6 (7.4–20.0)<0.001
Baseline cardiac index, l/min/m23.3 (2.8–4.3)2.9 (2.2–3.8)0.0183.2 (2.7–4.4)2.9 (2.4–4.0)0.0823.2 (2.8–4.4)3.0 (2.4–4.0)0.251
AVT cardiac index, l/min/m23.6 (2.9–4.5)3.1 (2.3–4.1)0.0033.8 (3.0–5.0)3.1 (2.3–3.9)<0.0014.2 (3.4–5.1)3.1 (2.4–4.0)<0.001
Baseline PVRi/SVRi0.8 (0.6–0.9)0.9 (0.7–1.2)0.0040.7 (0.5–0.9)0.9 (0.7–1.1)0.0010.7 (0.5–0.8)0.9 (0.7–1.1)<0.001
AVT PVRi/SVRi0.4 (0.2–0.6)0.7 (0.5–1.0)<0.0010.4 (0.2–0.5)0.7 (0.5–1.0)<0.0010.3 (0.2–0.4)0.7 (0.4–1.0)<0.001
Baseline mPAP/mSAP0.8 (0.6–1.0)0.9 (0.7–1.1)0.0070.8 (0.6–1.0)0.9 (0.7–1.1)0.0040.7 (0.6–0.9)0.9 (0.7–1.1)<0.001
AVT mPAP/mSAP0.5 (0.3–0.7)0.8 (0.6–1.0)<0.0010.4 (0.3–0.6)0.8 (0.6–1.0)<0.0010.4 (0.3–0.5)0.7 (0.5–1.0)<0.001
AVT agent
 iNO (and O2)50 (64.1)102 (76.1)0.06147 (75.8)102 (71.3)0.50923 (71.9)129 (71.7)0.981
 Other28 (35.9)32 (23.9)15 (24.2)41 (28.7)9 (28.1)51 (28.3)

Values are median (interquartile range), n (%), or mean ± SD.

mSAP = mean systemic arterial pressure; SVRi = systemic vascular resistance index; other abbreviations as in Tables 1 and 2.