Table 1

Baseline Characteristics

No ACEI/ARB at Discharge
(n = 18,745; 29.1%)
ACEI/ARB at Discharge
(n = 45,697; 70.9%)
Demographics
 Age, yrs74 (62–83)71 (62–80)
 Men11,351 (60.6)29,950 (65.5)
 Smoking (n = 58,987)3,917 (24.8) [1,903]9,623 (23.0) [3,552]
Discharge year
 20065,608 (29.9)10,904 (23.9)
 20075,066 (27.0)11,883 (26.0)
 20084,323 (23.1)11,643 (25.5)
 20093,748 (20.0)11,267 (24.7)
Creatinine, μmol/l84 (70–106)84 (71–102)
eGFR, ml/min/1.73 m273 (51–89)74 (56–89)
eGFR strata, ml/min/1.73 m2
 >6012,366 (66.0)32,124 (70.3)
 >45–602,715 (14.5)7,386 (16.2)
 >30–452,028 (10.8)4,319 (9.5)
 ≤30 (nondialysis)1,464 (7.8)1,687 (3.7)
 Dialysis173 (0.9)181 (0.4)
Renal transplantation on admission46 (0.2)69 (0.2)
Comorbidity at admission
 Diabetes mellitus3,084 (16.5)12,368 (27.1)
 Hypertension7,677 (41.0)27,648 (60.5)
 Previous MI4,383 (23.4)12,078 (26.4)
 HF3,255 (17.4)10,750 (23.5)
 Peripheral vascular disease1,019 (5.4)2630 (5.8)
 Previous stroke (any)2,601 (13.9)6,240 (13.7)
 COPD1,921 (10.2)4,364 (9.5)
 Cancer diagnosis within the past 3 yrs576 (3.1)1,072 (2.3)
 Previous PCI1,636 (8.7)5,460 (11.9)
 Previous CABG1,337 (7.1)4,196 (9.2)
 Atrial fibrillation2,187 (11.7)5,147 (11.3)
Hospital course
 Decompensated HF (Killip ≥2)2,439 (13.5)6,271 (14.4)
 STEMI4,233 (22.8)1,4526 (32.0)
 NSTEMI (n = 63,913)14,350 (77.2) [162]30,804 (68.0) [367]
 PCI7,991 (42.6)26,262 (57.5)
 CABG523 (2.8)847 (1.9)
 LVEF <50% (n = 44,502)3,137 (28.3) [7,666]17,414 (52.1) [12,274]
 Intravenous inotrope330 (1.8)1095 (2.4)
 Intravenous diuretic agent3,713 (19.9)11,024 (24.2)
Medication at discharge
 Aspirin16,931 (90.6)42,438 (92.9)
 Mono antiplatelet therapy5,727 (30.6)9,776 (21.4)
 Dual antiplatelet therapy11,739 (62.8)34,027 (74.5)
 Warfarin925 (5.0)3,242 (7.1)
 Beta-blocker15,879 (85.0)41,454 (90.7)
 Calcium antagonist2,621 (14.0)7,205 (15.8)
 Digoxin735 (3.9)1,735 (3.8)
 Diuretic agent58,05 (31.1)17,146 (37.5)
 Statin13,522 (72.4)39,425 (86.3)
No ACEI on admission17,440 (93.0)31,385 (68.7)
No ARB on admission17,831 (95.1)36,704 (80.3)

Values are median (interquartile range) or n (%) [missing number of patients], unless otherwise indicated.

ACEI = angiotensin-converting enzyme inhibitor; ARB = angiotensin receptor blocker; CABG = coronary artery bypass graft; COPD = chronic obstructive pulmonary disease; eGFR = estimated glomerular filtration rate; HF = heart failure; LVEF = left ventricular ejection fraction; MI = myocardial infarction; NSTEMI = non–ST-segment elevation myocardial infarction; PCI = percutaneous coronary intervention; STEMI = ST-segment elevation myocardial infarction.

  • Values are n (% of patients included).