Table 4

ApoB, Cholesterol Levels, and Concordance/Discordance Between ApoB and Cholesterol Categories in Relation to Risk of Y25 CAC>0

OR (95% CI)
UnadjustedModel 1Model 2Model 3
ApoB tertiles
 Low (referent) (n = 915)1.001.001.001.00
 Middle (n = 944)1.77 (1.41–2.21)1.62 (1.28–2.04)1.58 (1.24–2.00)1.53 (1.20–1.94)
 High (n = 935)3.06 (2.47-3.80)2.81 (2.24–3.53)2.49 (1.97–3.15)2.28 (1.79–2.89)
LDL-C§ tertiles
 Low (referent) (n = 929)1.001.001.001.00
 Middle (n = 924)1.51 (1.22–1.88)1.45 (1.15–1.83)1.47 (1.16–1.86)1.41 (1.11–1.80)
 High (n = 941)2.65 (2.15–3.27)2.50 (2.00–3.12)2.37 (1.88–2.99)2.23 (1.77–2.82)
NHDL-C tertiles
 Low (referent) (n = 923)1.001.001.001.00
 Middle (n = 927)1.62 (1.29–2.02)1.52 (1.20–1.92)1.47 (1.16–1.87)1.40 (1.10–1.78)
 High (n = 944)3.13 (2.53–3.88)2.79 (2.23–3.50)2.54 (2.01–3.22)2.32 (1.83–2.95)
ApoB/LDL-C
 Low/low (referent) (n = 1,153)1.001.001.001.00
 Low/high (n = 244)1.40# (1.01–1.93)1.30 (0.92–1.82)1.30 (0.92–1.85)1.29 (0.91–1.83)
 High/low (n = 241)1.79 (1.31–2.44)1.89 (1.36–2.62)1.66 (1.18–2.33)1.55 (1.10–2.18)
 High/high (n = 1,156)2.48 (2.06–3.00)2.30 (1.88–2.81)2.09 (1.70–2.57)1.94 (1.58–2.40)
ApoB/NHDL-C
 Low/low (referent) (n = 1,184)1.001.001.001.00
 Low/high (n = 213)1.42# (1.01–1.99)1.30 (0.91–1.85)1.23 (0.85–1.77)1.19 (0.82–1.72)
 High/low (n = 217)1.49# (1.06–2.08)1.63 (1.15–2.32)1.51# (1.05–2.17)1.45# (1.01–2.09)
 High/high (n = 1,180)2.53 (2.10–3.04)2.32 (1.91–2.83)2.07 (1.69–2.54)1.91 (1.55–2.35)

CI = confidence interval; OR = odds ratio; other abbreviations as in Table 1.

  • Model 1: adjusted for age, sex and race; Model 2: Model 1 + baseline (smoking status, systolic BP, antihypertensive medication use, diabetes, and BMI); Model 3: Model 2 + HDL-C and lipid-lowering medication use.

  • Median apoB: 88 g/dl.

  • p < 0.001 compared with the referent group.

  • § Median LDL-C: 107 mg/dl.

  • p < 0.01 compared with the referent group.

  • Median NHDL-C: 121 mg/dl.

  • # p < 0.5 compared with the referent group.