Table 4

Association Between NIT Result and the Primary Composite Outcome

Event Rate
No. of Events/Sample Size (%)
Positive Versus Negative Results, UnadjustedPositive Versus Negative Results, Adjusted
Positive Test ResultNegative Test ResultHR (95% CI)p ValueHR (95% CI)p Value
Interaction between test result, test type, and sex0.0200.010
Women
 Association of test positivity in women randomized to CTA18/184 (9.78)39/2,148 (1.82)6.39 (3.65-11.17)<0.0015.86 (3.32-10.35)<0.001
 Association of test positivity in women randomized to stress test14/274 (5.11)41/2,114 (1.94)2.70 (1.45-5.03)0.0022.27 (1.21-4.25)0.011
 Difference between the association in CTA and the association in stress test0.0430.028
Men
 Association of test positivity in men randomized to CTA31/350 (8.86)49/1,818 (2.70)3.69 (2.35-5.79)<0.0012.80 (1.76-4.45)<0.001
 Association of test positivity in men randomized to stress test33/290 (11.38)40/1,788 (2.24)5.39 (3.39-8.56)<0.0014.42 (2.77-7.07)<0.001
 Difference between the association in CTA and the association in stress test0.2490.168

HR = hazard ratio; other abbreviations as in Tables 1 and 3.

  • Unadjusted models contained test result, randomized testing arm, sex, and all 2- and 3-way interaction terms.

  • Adjusted for the same factors as in Table 3.