Table 3

Hazard Ratios for Disease-Specific Mortality and Nonfatal CVD, by CRF Level, in Women (n = 9,145)

Measured CRFEstimated CRF
n/NHazard Ratio (95% CI)n/NHazard Ratio (95% CI)
Model 1Model 2Model 1Model 2
All-cause mortality
 Lower109/3,1431 (Ref)1 (Ref)74/3,0481 (Ref)1 (Ref)
 Middle66/3,0760.92 (0.68–1.25)0.91 (0.67–1.24)77/3,0490.83 (0.60–1.14)0.82 (0.59–1.13)
 Upper41/2,9260.75 (0.52–1.07)0.74 (0.52–1.07)65/3,0480.68 (0.49–0.95)0.67 (0.48–0.94)
 p for linear trend0.2810.2750.0790.068
 Per 1-MET increase0.92 (0.85–0.99)0.91 (0.85–0.99)0.87 (0.75–0.99)0.87 (0.75–0.99)
CVD-related mortality
 Lower25/3,1431 (Ref)1 (Ref)21/3,0481 (Ref)1 (Ref)
 Middle16/3,0761.05 (0.56–1.97)1.08 (0.57–2.04)15/3,0490.63 (0.32–1.22)0.70 (0.35–1.37)
 Upper9/2,9260.80 (0.37–1.72)0.89 (0.41–1.94)14/3,0480.58 (0.29–1.17)0.65 (0.32–1.31)
 p for linear trend0.7930.9050.2300.410
 Per 1-MET increase0.92 (0.78–1.09)0.95 (0.81–1.13)0.83 (0.63–1.08)0.84 (0.64–1.12)
Nonfatal CVD
 Lower42/1,2061 (Ref)1 (Ref)27/1,0241 (Ref)1 (Ref)
 Middle15/1,1750.35 (0.19–0.63)0.36 (0.20–0.66)27/1,2390.64 (0.38–1.11)0.73 (0.42–1.26)
 Upper15/1,2540.35 (0.19–0.63)0.38 (0.21–0.69)18/1,3720.34 (0.19–0.63)0.38 (0.20–0.70)
 p for linear trend< 0.001< 0.0010.0030.008
 Per 1-MET increase0.75 (0.65–0.87)0.77 (0.67–0.90)0.69 (0.54–0.89)0.76 (0.58–0.99)

Abbreviations as in Tables 1 and 2.

  • Adjusted for age and examination year.

  • Adjusted for age, examination year, alcohol intake (heavy drinker or not), hypercholesterolemia, hypertension, diabetes, abnormal resting or exercise ECG, and parental history of CVD (present or not for each).