Table 1

Baseline Characteristics of the Adults 40 to 75 Years of Age With and Without Diabetes Mellitus, Stratified According to Predicted ASCVD Risk Category

10-Year Predicted Risk of ASCVD Eventsp Value
Overall
(N = 307,591)
<5%
(n = 175,605)
5% to <7.50%
(n = 36,896)
7.50% to <10%
(n = 25,142)
≥10%
(n = 69,948)
No diabetes mellitus
 10-yr predicted risk of ASCVD
  Mean ± SD6.60 ± 7.022.08 ± 1.336.16 ± 0.728.68 ± 0.7217.43 ± 6.42<0.001
  Median (IQR)3.94 (1.56–9.22)1.81 (0.92–3.08)6.12 (5.54–6.76)8.64 (8.05–9.29)15.70 (12.37–20.88)<0.001
  Range0.04–65.640.04–5.005.00–7.507.50–10.0010.00–65.64
 Age, yrs54.8 ± 9.149.8 ± 6.156.1 ± 6.858.6 ± 7.065.1 ± 7.2<0.001
 Female189,511 (61.6)134,990 (76.9)18,745 (50.8)11,207 (44.6)24,569 (35.1)<0.001
 Race/ethnicity<0.001
  White/European (non-Hispanic)212,039 (68.9)115,652 (65.9)26,303 (71.3)18,067 (71.9)52,017 (74.4)
  Black/African American (non-Hispanic)22,283 (7.2)10,164 (5.8)3,414 (9.3)2,427 (9.7)6,278 (9.0)
  Asian/Pacific Islander52,917 (17.2)36,831 (21.0)5,099 (13.8)3,296 (13.1)7,691 (11.0)
  Hispanic18,745 (6.1)12,035 (6.9)1,875 (5.1)1,222 (4.9)3,613 (5.2)
  Other/unknown1,607 (0.5)923 (0.5)205 (0.6)130 (0.5)349 (0.5)
 Residential block-level socioeconomic status
  Median household income<0.001
   ≥$35,000295,497 (96.1)169,441 (96.5)35,360 (95.8)23,984 (95.4)66,712 (95.4)
   <$35,00011,772 (3.8)6,004 (3.4)1,493 (4.0)1,118 (4.4)3,157 (4.5)
   Missing322 (0.1)160 (0.1)43 (0.1)40 (0.2)79 (0.1)
  Highest level of education<0.001
   High school graduate or higher275,867 (89.7)157,925 (89.9)33,073 (89.6)22,461 (89.3)62,408 (89.2)
   Less than high school31,409 (10.2)17,524 (10.0)3,781 (10.2)2,641 (10.5)7,463 (10.7)
   Missing315 (0.1)156 (0.1)42 (0.1)40 (0.2)77 (0.1)
 Tobacco use<0.001
  Current29,537 (9.6)10,022 (5.7)5134 (13.9)3,929 (15.6)10,452 (14.9)
  Former67,611 (22.0)19,316 (11.0)9,762 (26.5)7,964 (31.7)30,569 (43.7)
  Never210,443 (68.4)146,267 (83.3)22,000 (59.6)13,249 (52.7)28,927 (41.4)
 Systolic blood pressure, mm Hg124.5 ± 15.0120.2 ± 13.8126.7 ± 13.5128.2 ± 13.8132.8 ± 15.1<0.001
 BMI, kg/m2<0.001
  <18.53,604 (1.2)2,249 (1.3)337 (0.9)235 (0.9)783 (1.1)
  18.5–24.9107,422 (34.9)70,931 (40.4)10,530 (28.5)6,978 (27.8)18,983 (27.1)
  25.0–29.9109,104 (35.5)57,729 (32.9)13,773 (37.3)9,544 (38.0)28,058 (40.1)
  30.0–39.976,401 (24.8)38,655 (22.0)10,645 (28.9)7,325 (29.1)19,776 (28.3)
  ≥408,620 (2.8)4,845 (2.8)1,272 (3.4)846 (3.4)1,657 (2.4)
  Missing2,440 (0.8)1,196 (0.7)339 (0.9)214 (0.9)691 (1.0)
 Antihypertensive medication use101,089 (32.9)34,085 (19.4)13,447 (36.4)10,733 (42.7)42,824 (61.2)<0.001
 Lipoproteins, mg/dl
  Total197.5 ± 29.7194.6 ± 29.0201.7 ± 29.7202.0 ± 30.1201.0 ± 30.5<0.001
  HDL-C55.6 ± 15.458.0 ± 15.153.4 ± 15.152.8 ± 15.251.7 ± 15.4<0.001
  LDL-C118.1 ± 24.4115.2 ± 23.9122.4 ± 24.4122.6 ± 24.7121.7 ± 24.4<0.001
10-year Predicted Risk of ASCVD Eventsp Value
Overall
(N = 4,242)
<5.00%
(n = 834)
5.00% to <7.50%
(n = 369)
7.50% to <10%
(n = 327)
≥10%
(n = 2,712)
Diabetes mellitus
 10-year predicted risk of ASCVD
  Mean ± SD26.81 ± 26.192.05 ± 1.396.19 ± 0.728.72 ± 0.7140.23 ± 24.33<0.001
  Median (IQR)17.36 (5.12–42.58)1.82 (0.82–3.11)6.13 (5.56–6.79)8.67 (8.12–9.32)34.49 (19.24–57.03)<0.001
  Range0.00–100.000.00–5.005.01–7.497.51–9.9910.01–100.00
 Age, yrs58.1 ± 9.647.6 ± 5.151.7 ± 6.154.0 ± 6.362.7 ± 8.0<0.001
 Female2,127 (50.1)663 (79.5)229 (62.1)209 (63.9)1,026 (37.8)<0.001
 Race/ethnicity<0.001
  White/European (non-Hispanic)2,371 (55.9)390 (46.8)221 (59.9)184 (56.3)1,576 (58.1)
  Black/African American (non-Hispanic)544 (12.8)55 (6.6)32 (8.7)36 (11.0)421 (15.5)
  Asian/Pacific Islander768 (18.1)253 (30.3)77 (20.9)62 (19.0)376 (13.9)
  Hispanic529 (12.5)127 (15.2)37 (10.0)42 (12.8)323 (11.9)
  Other/unknown30 (0.7)9 (1.1)2 (0.5)3 (0.9)16 (0.6)
 Residential block-level socioeconomic status
  Median household income0.57
   ≥$35,0003,971 (93.6)791 (94.8)349 (94.6)306 (93.6)2,525 (93.1)
   <$35,000268 (6.3)42 (5.0)20 (5.4)21 (6.4)185 (6.8)
   Missing3 (0.1)1 (0.1)002 (0.1)
  Highest level of education0.76
   High school graduate or higher3,534 (83.3)705 (84.5)311 (84.3)275 (84.1)2,243 (82.7)
   Less than high school706 (16.6)128 (15.3)58 (15.7)52 (15.9)468 (17.3)
   Missing2 (0.0)1 (0.1)001 (0.0)
 Tobacco use<0.001
  Current481 (11.3)29 (3.5)31 (8.4)46 (14.1)375 (13.8)
  Former1,227 (28.9)28 (3.4)49 (13.3)69 (21.1)1,081 (39.9)
  Never2,534 (59.7)777 (93.2)289 (78.3)212 (64.8)1,256 (46.3)
 Systolic blood pressure, mm Hg129.5 ± 16.6122.3 ± 13.7126.9 ± 15.5128.5 ± 15.01,32.3 ± 16.9<0.001
 BMI, kg/m2<0.001
  <18.550 (1.2)12 (1.4)2 (0.5)2 (0.6)34 (1.3)
  18.5–24.9716 (16.9)183 (21.9)55 (14.9)42 (12.8)436 (16.1)
  25.0–29.91,137 (26.8)208 (24.9)84 (22.8)88 (26.9)757 (27.9)
  30.0–39.91,924 (45.4)325 (39.0)191 (51.8)161 (49.2)1,247 (46.0)
  ≥40389 (9.2)102 (12.2)36 (9.8)32 (9.8)219 (8.1)
  Missing26 (0.6)4 (0.5)1 (0.3)2 (0.6)19 (0.7)
 Antihypertensive medication use2,924 (68.9)410 (49.2)199 (53.9)191 (58.4)2,124 (78.3)<0.001
 Lipoproteins, mg/dl
  Total175.9 ± 31.1174.9 ± 27.7178.7 ± 30.0180.5 ± 33.6175.3 ± 31.8<0.01
  HDL-C47.9 ± 13.953.7 ± 14.448.6 ± 13.949.5 ± 14.545.8 ± 13.1<0.001
  LDL-C99.7 ± 23.497.8 ± 20.9101.3 ± 23.5101.9 ± 25.699.7 ± 23.8<0.05

Values are mean ± SD or n (%), unless otherwise indicated.

ASCVD = atherosclerotic cardiovascular disease; BMI = body mass index; HDL-C = high-density lipoprotein cholesterol; IQR = interquartile range; LDL-C = low-density lipoprotein cholesterol.