Table 5

Major Implantable Cardioverter-Defibrillator Trials for Prevention of Sudden Cardiac Death

TrialYearPatients (n)Inclusion Criterion: LVEF % Less Than or Equal toOther Inclusion CriteriaHazard Ratio95% Confidence Intervalp
MADIT I (327)199619635NSVT and positive EP0.460.26 to 0.820.009
MADIT II (332)20021,23230Prior MI0.690.51 to 0.930.016
CABG-Patch (328)199790036Positive SAECG and CABG1.070.81 to 1.420.64
DEFINITE (369)200448535NICM, PVCs, or NSVT0.650.40 to 1.060.08
DINAMIT (331)2004674356 to 40 days after MI and impaired HRV1.080.76 to 1.550.66
SCD-HeFT (333)20051,67635Prior MI or NICM0.770.62 to 0.960.007
AVID (319)19971,01640Prior cardiac arrest0.620.43 to 0.82<0.02
CASH (323)2000191M: 45±18 at baselinePrior cardiac arrest0.771.1120.081§
CIDS (322)200065935Prior cardiac arrest, syncope0.820.60 to 1.10NS

AVID indicates Antiarrhythmics Versus Implantable Defibrillators; CABG, coronary artery bypass graft surgery; CASH, Cardiac Arrest Study Hamburg; CIDS, Canadian Implantable Defibrillator Study; DEFINITE, Defibrillators in Nonischemic Cardiomyopathy Treatment Evaluation; DINAMIT, Defibrillator in Acute Myocardial Infarction Trial; EP, electrophysiological study; HRV, heart rate variability; LVD, left ventricular dysfunction; LVEF, left ventricular ejection fraction; MADIT I, Multicenter Automatic Defibrillator Implantation Trial I; MADIT II, Multicenter Automatic Defibrillator Implantation Trial II; MI, myocardial infarction; NA, not applicable; NICM, nonischemic cardiomyopathy; NS, not statistically significant; NSVT, nonsustained ventricular tachycardia; PVCs, premature ventricular complexes; SAECG, signal-averaged electrocardiogram; and SCD-HeFT, Sudden Cardiac Death in Heart Failure Trial.

  • Hazard ratios for death due to any cause in the implantable cardioverter-defibrillator group compared with the non-implantable cardioverter-defibrillator group.

  • Includes only implantable cardioverter-defibrillator and amiodarone patients from CASH.

  • Upper bound of 97.5% confidence interval.

  • § One-tailed.