Table 3

Association of Substantial Biomarker Changes at 48 h From Randomization With 180-Day Mortality in the Relaxin in Acute Heart Failure Study

Biomarker Change From Baseline to Day 2Death Through Day 180HR (95% CI)p Value
NoYes
Troponin (≥20% increase)62/82530/2311.80 (1.16–2.777)0.0076
7.6 (6.0–9.6)13.1 (9.3–18.2)
Creatinine (≥27 μmol/l [0.3 mg/dl] increase)75/91923/1671.76 (1.11–2.82)0.016
8.2 (6.6–10.2)13.8 (9.4–20.0)
Cystatin-C (≥22 nmol/l [0.3 mg/l] increase)66/86932/2122.10 (1.38–3.20)0.0004
7.7 (6.1–9.7)15.2 (11.0–20.7)
AST (≥20% increase)73/90613/991.66 (0.92–3.00)0.099
8.1 (6.5–10.1)13.4 (8.0–22.0)
ALT (≥20% increase)79/97015/991.96 (1.13–3.40)0.015
8.2 (6.6–10.1)15.3 (9.5–24.1)
NT-proBNP (≥30% decrease)53/39545/6860.47 (0.31–0.69)0.0001
13.5 (10.5–17.4)6.6 (5.0–8.8)

Values are n/N with Kaplan-Meier percentages and 95% CIs.

ALT = alanine transaminase; AST = aspartate transaminase. Other abbreviations as in Tables 1 and 2.