Table 1

Characteristics of the Study Population

ParameterOverall (n = 1,195)Normal MPS (n = 1,119)*Ischemic MPS (n = 76)p Values
Age, yrs58.4 ± 10.358.1 ± 10.261.9 ± 11.10.0028
Female326 (27.3%)318 (28.4%)8 (10.5%)0.001
Symptom class
 Asymtomatic609 (51.0%)572 (51.1%)37 (48.7%)0.681
 Asymptomatic/SOB658 (55.1%)621 (55.5%)37 (48.7%)0.248
 Non-anginal pain112 (9.4%)108 (9.7%)4 (5.3%)0.204
 Atypical angina380 (31.8%)359 (32.1%)21 (27.6%)0.420
 Typical angina45 (3.8%)31 (2.8%)14 (18.4%)<0.0001
Risk factors
 High cholesterol897 (75.1%)844 (75.4%)53 (69.7%)0.267
 Hypertension514 (43.0%)465 (41.6%)49 (64.5%)<0.0001
 Family history448 (37.5%)414 (37.0%)34 (44.7%)0.177
 Diabetes138 (11.6%)126 (11.3%)12 (15.8%)0.232
 Smoking84 (7.0%)78 (7.0%)6 (7.9%)0.760
 BMI26.9 ± 4.826.8 ± 4.727.9 ± 5.20.1028
CAC score438.9 ± 703.4388.9 ± 617.01,175.0 ± 1,272.0<0.0001
Pre-rest likelihood of CAD (%)24.4 ± 24.123.6 ± 23.136.6 ± 33.60.0019
Exercise stress test*n = 1,049n = 989n = 58
 Ischemic stress ECG220 (21.0%)184 (18.6%)36 (62.1%)<0.0001
 Exercise time9.3 ± 2.79.4 ± 2.77.9 ± 2.80.0001
 Exercise chest pain83 (7.9%)62 (6.3%)21 (36.2%)<0.0001
 Rest HR68.2 ± 12.268.3 ± 12.167.7 ± 13.90.738
 Peak HR154.3 ± 14.8155 ± 14.4142.1 ± 16.6<0.0001
 Rest SBP136.7 ± 18.6136.4 ± 18.7142.1 ± 17.70.0209
 Peak SBP171.6 ± 20.7171.8 ± 20.8167.8 ± 18.40.0910
 Rest DBP80.4 ± 9.380.3 ± 9.283.3 ± 9.60.0250
 Peak DBP77.2 ± 9.777.0 ± 9.681.0 ± 10.90.0017

BMI = body mass index; CAC = coronary artery calcium; CAD = coronary artery disease; HR = heart rate; MPS = myocardial perfusion single-photon emission computed tomography; SBP = systolic blood pressure; SOB = shortness of breath.

  • * Adenosine stress excluded.