Table 1

Hemodynamic Data (mean ± SEM)

ControlLCx OcΔP-ILCx OcΔP-IILCx OcD2.5LCx OcD5LCx OcD5+ΔP-IILCx OcHalo (n = 4)LCx Oc
HR126 ± 7128 ± 7126 ± 7130 ± 9127 ± 7134 ± 10143 ± 6146 ± 6150 ± 9157 ± 10150 ± 13159 ± 11125 ± 13122 ± 16
LVP103 ± 582 ± 4a109 ± 587 ± 5a103 ± 594 ± 6a126 ± 1c102 ± 4a128 ± 9c103 ± 5a154 ± 5cef120 ± 4a72 ± 9c57 ± 6b
EDP10.5 ± 0.914.5 ± 0.8b10.5 ± 0.715.9 ± 1.4b10.6 ± 1.019.3 ± 1.7b14.7 ± 2.121.7 ± 2.3b11.9 ± 2.117.6 ± 2.4b15.1 ± 2.121.0 ± 2.3b11.6 ± 1.614.0 ± 1.5
+dP/dt1.709 ± 691,208 ± 72a1,590 ± 1051,192 ± 114b1,659 ± 811,228 ± 125b2,417 ± 189c1,851 ± 98a2,794 ± 171ce2,037 ± 120a2,672 ± 153c2,108 ± 113a1,011 ± 258d710 ± 192b
  • a p < 0.01,

  • b p < 0.05, left circumflex coronary artery occlusion (LCx Oc) versus pre-LCx Oc for each intervention.

  • c p < 0.01,

  • d p < 0.05 versus Control.

  • e p < 0.01, dobutamine, 5 μg/kg per min (D5) versus dobutamine, 2.5 μg/kg per min (D2.5).

  • f p < 0.01, D5 plus increase in aortic pressure of 15 to 20 mm Hg during descending aortic constriction (ΔP-II) versus D5 alone. EDP = end-diastolic left ventricular pressure (LVP) (mm Hg); halo = 2.5% halothane; HR = heart rate (beats/min); +dP/dt (mmHg/s) = first derivative of peak positive LVP; ΔP-I = increase in aortic pressure of 5 to 10 mm Hg during descending aortic constriction.