Table 1

Arterial Morphologic Characteristics of Different Groups of Balloon-Injured Animals Included in the Studylegend legend

Neointima (mm2)% Change vs. Control Groupp Value vs. Control GroupMedia (mm2)p Value vs. Control GroupN/M Ratio% Change vs. Control Groupp Value vs. Control Group
Control rats (n = 8)0.266 ± 0.0150.208 ± 0.0351.271 ± 0.074
Simvastatin
 0.04 mg/kg (n = 9)0.219 ± 0.020−24%NS0.210 ± 0.020NS1.045 ± 0.033−18%NS
Simvastatin
 4 mg/kg (n = 7)0.212 ± 0.006−26%NS0.208 ± 0.018NS1.023 ± 0.040−20%NS
Simvastatin
 16 mg/kg (n = 7)0.176 ± 0.009−32%< 0.050.205 ± 0.028NS0.866 ± 0.050−32%< 0.05
Simvastatin
 40 mg/kg (n = 8)0.080 ± 0.026−69%< 0.0010.170 ± 0.064NS0.436 ± 0.158−66%< 0.001
Simvastatin
 40 mg/kg + mevalonate0.256 ± 0.011−1%NS0.207 ± 0.040NS1.258 ± 0.084−2%NS
 10 mmol/liter (n = 5)
  • legend Data are expressed as the mean value ± SEM.

  • legend N/M = neointima-media.