Table 1

Baseline Characteristics of 84 Subjects With Type I Diabetes Mellituslegend

Treatment Groups
Placebol-ArginineAtorvastatinl-Arginine Plus Atorvastatin
Male22 (77%)21 (72%)21 (53%)20 (55%)
Age (yrs)34.9 ± 7.935.0 ± 6.433.7 ± 6.133.3 ± 6.8
Microalbuminuria4042
Duration of diabetes (years)16.5 ± 9.615.0 ± 9.215.1 ± 8.516.2 ± 10.2
Fructosamine (μmol/liter)408 ± 73374 ± 75427 ± 64414 ± 64
Glucose (mmol/liter)10.8 ± 6.29.9 ± 6.110.6 ± 5.111.4 ± 5.1
Daily insulin (IU)52.8 ± 17.464.2 ± 22.553.3 ± 25.650.5 ± 15.6
Arginine (μmol/liter)57.5 ± 15.668.9 ± 17.670.1 ± 28.665.2 ± 12.6
Total cholesterol (mmol/liter)4.70 ± 1.074.78 ± 0.804.92 ± 1.075.08 ± 0.86
LDL cholesterol (mmol/liter)2.82 ± 1.02.95 ± 0.813.08 ± 0.923.02 ± 0.82
HDL cholesterol (mmol/liter)1.45 ± 0.331.34 ± 0.461.47 ± 0.371.62 ± 0.62
Triglycerides (mmol/liter)0.93 ± 0.511.09 ± 1.080.83 ± 0.440.97 ± 0.34
SBP (mm Hg)122 ± 13127 ± 11122 ± 14120 ± 12
DBP (mm Hg)73 ± 775 ± 875 ± 972 ± 6
Rest vessel size (mm)3.93 ± 0.474.05 ± 0.653.69 ± 0.703.77 ± 0.73
FMD (%)3.49 ± 2.993.33 ± 3.033.65 ± 3.203.01 ± 3.32
GTN-MD (%)17.12 ± 8.4916.44 ± 7.4919.58 ± 8.0016.07 ± 7.49
Rest blood flow (ml/min)83.0 ± 48.0110.6 ± 69.765.9 ± 53.086.0 ± 61.1
Hyperemic blood flow (AUC)75.7 ± 26.589.3 ± 41.969.8 ± 29.078.6 ± 35.7
  • AUC = area under the time–flow curve for hyperemic blood flow over the first 20 s after release of the tourniquet. Data are presented as the number (%) of patients or mean value ± SD.

  • legend DBP = diastolic blood pressure; FMD = flow-mediated dilatation; GTN-MD = glyceryl trinitrate mediated dilatation; HDL = high-density lipoprotein; LDL = low-density lipoprotein; SBP = systolic blood pressure.