Table 6

Dose-Related Changes in Neurohormone Levels Over 12 Weekslegend

VariableOmapatrilat Dosep Value
2.5 mg5–10 mg20–40 mg
ANP predose, day 169 ± 1077 ± 852 ± 10NS
ANP predose, week 1261 ± 872 ± 1364 ± 18NS
BNP predose, day 161 ± 943 ± 542 ± 10NS
BNP predose, week 1254 ± 840 ± 434 ± 9NS
ET-1 predose, day 12.6 ± 0.22.8 ± 0.21.7 ± 0.2< 0.001
ET-1 predose, week 122.4 ± 0.12.4 ± 0.11.9 ± 0.2< 0.01
EPI predose, day 1144 ± 29178 ± 38154 ± 23NS
EPI predose, week 1295 ± 2688 ± 13118 ± 14NS
NE predose, day 12,680 ± 2902,263 ± 2182,271 ± 204NS
NE predose, week 122,650 ± 2372,087 ± 2522,284 ± 251NS
ALD predose, day 1303 ± 54200 ± 29246 ± 53NS
ALD predose, week 12187 ± 32198 ± 36193 ± 51NS
  • Significant difference between groups.

  • p < 0.05 within group.

  • p < 0.01 within group compared with predose day 1. Data are presented as the mean value ± SEM in pmol/liter.

  • legend ALD = aldosterone; ANP = atrial natriuretic peptide; BNP = brain natriuretic peptide; EPI = epinephrine; ET-1 = endothelin-1; NE = norepinephrine.