Variable | Univariate Analysis | Multivariate Analysis∗ | ||||
---|---|---|---|---|---|---|

Chi-Square | p Value | OR (95% CI) | Chi-Square | p Value | OR (95% CI) | |

Extent of CAD | 385 | < 0.001 | 2.8 (2.5–3.1) | 267 | < 0.001 | 2.5 (2.3–2.8) |

SRS†(1-point increase) | 207 | < 0.001 | 1.13 (1.11–1.15) | 57 | < 0.001 | 1.07 (1.06–1.09) |

SSS‡(5-point decrease) | 186 | < 0.001 | 1.5 (1.4–1.6) | — | — | — |

Chest pain class | 114 | < 0.001 | 1.5 (1.4–1.7) | 62 | < 0.001 | 1.4 (1.3–1.6) |

Age (10-year increase) | 54 | < 0.001 | 1.4 (1.3–1.5) | — | — | — |

Symptom status | 49 | < 0.001 | 2.3 (1.8–2.9) | — | — | — |

Hyperlipidemia | 14 | < 0.001 | 1.4 (1.2–1.7) | — | — | — |

Cardiac enlargement | 9 | 0.003 | 1.4 (1.1–2.6) | — | — | — |

Gender (male) | 7 | 0.010 | 1.3 (1.1–1.6) | — | — | — |

Pharmacologic stress | 7 | 0.010 | 0.8 (0.6–0.9) | 6 | 0.014 | 0.7 (0.6–0.9) |

Hypertension | 6 | 0.02 | 1.2 (1.0–1.5) | — | — | — |

Smoking | 1 | NS | 1.1 (0.9–1.2) | — | — | — |

Diabetes | < 1 | NS | 0.9 (0.8–1.1) | — | — | — |

↵∗ Variables without numbers in the multivariate analysis did not meet the entry criteria into the final model;

↵† a summed reversibility score (SRS) of 0 represents a nonischemic image;

↵‡ a summed stress score (SSS) of 56 represents a normal image. Final model: chi-square = 652, p < 0.001; C-index = 0.82. Bootstrapping analysis the extent of CAD came into every model, SRS and chest pain class in 98% of the models and pharmacologic stress in 64%. In the initial multivariate stepwise analysis, symptom status just met the entry criteria into the model (chi-square = 4, p = 0.038). In the bootstrapping analysis, it came into only 13% of the models. This variable was therefore eliminated from the final multivariate model.

↵legend CAD = coronary artery disease; other abbreviations as in Table 3.