Variable | Univariate Analysis | Multivariate Analysis∗ | ||||
---|---|---|---|---|---|---|

Chi-Square | p Value | OR (95% CI) | Chi-Square | p Value | OR (95% CI) | |

SSS†(5-point decrease) | 2,066 | < 0.001 | 2.4 (2.3–2.5) | 147 | <0.001 | 1.5 (1.4–1.6) |

SRS‡(1-point increase) | 2,020 | < 0.001 | 1.3 (1.29–1.32) | 273 | <0.001 | 1.18 (1.17–1.20) |

Cardiac enlargement | 502 | < 0.001 | 3.9 (3.3–4.3) | — | — | — |

Gender (male) | 202 | < 0.001 | 2.2 (2.0–2.5) | 16 | <0.001 | 1.3 (1.1–1.5) |

Chest pain class | 62 | < 0.001 | 1.2 (1.1–1.2) | — | — | — |

Diabetes | 56 | < 0.001 | 1.3 (1.2–1.4) | — | — | — |

Smoking | 23 | < 0.001 | 1.2 (1.1–1.3) | 4 | 0.047 | 1.1 (1.0–1.2) |

Symptom status | 22 | < 0.001 | 1.3 (1.2–1.5) | 17 | <0.001 | 1.3 (1.2–1.5) |

Pharmacologic stress | 14 | < 0.001 | 1.2 (1.1–1.4) | 9 | 0.003 | 1.2 (1.1–1.4) |

Age (10-year increase) | 10 | 0.002 | 1.07 (1.03–1.11) | 27 | <0.001 | 0.87 (0.82–0.91) |

Hypertension | 9 | 0.004 | 1.2 (1.1–1.3) | — | — | — |

Hyperlipidemia | 5 | 0.034 | 1.1 (1.0–1.2) | — | — | — |

↵∗ Variables without numbers in the multivariate analysis did not meet the entry criteria into the final model;

↵† a summed stress score (SSS) of 56 represents a normal image;

↵‡ a summed reversibility score (SRS) of 0 represents a nonischemic image. Final model: chi-square = 3,051, p < 0.001, C-index = 0.87. Bootstrapping analysis SSS and SRS came into every model, symptom status in >99% of the models, gender in 97%, pharmacologic stress in 81% and age in 79%.

↵legend CI = confidence interval; OR = odds ratio.