Table 1

Baseline Characteristics of the Study Population by Level of Kidney Function and Hematocritlegend legend

CharacteristicsAll (n = 6,635)Level of Kidney Function (GFR ml/min/1.73 m2)Level of Hematocrit (%)
<60 (n = 2,106)60–75 (n = 2,133)>75 (n = 2,391)p Value<35 (n = 290)35–39 (n = 1,145)≥40 (n = 5,128)p Value
Demographics
Age60 (10.3)65 (8.1)60 (9.7)56 (10.7)< 0.00162 (11.1)60 (10.0)59 (10.2)< 0.001
Gender (% male)86808989< 0.001697290< 0.001
Ethnic origin (% white)84878681< 0.001777886< 0.001
Ejection fraction27 (6.3)27 (6.3)27 (6.4)27 (6.2)0.0427 (6.1)27 (6.2)27 (6.3)0.931
Etiology of LV dysfunction (% ischemic)797981770.0157677800.047
NYHA class< 0.001< 0.001
I46364952373948
II42464040434342
III and IV1218118201910
Trial assignment (% treatment)38493431< 0.001474535< 0.001
Treatment assignment (% enalapril)505049510.584949500.668
Previous medication use
Beta-blockers18151920< 0.001131419< 0.001
Diuretic42563934< 0.001474940< 0.001
Digoxin33393129< 0.0013937320.001
Antiarrhythmic agents18241814< 0.0012618170.001
Past medical history
Hypertension39463734< 0.0014340380.134
Diabetes19231717< 0.0012723180.003
Myocardial infarction757478740.0046773760.002
Physical exam
Systolic blood pressure (mm Hg)125 (17.0)127 (18.0)125 (16.6)124 (16.2)< 0.001125 (18.4)124 (17.6)125 (16.7)0.122
Diastolic blood pressure (mm Hg)77 (9.9)77 (10.2)78 (9.7)78 (9.7)0.00175 (10.2)76 (10.0)78 (9.7)< 0.001
Laboratory data
Creatinine (mg/dl)1.18 (0.3)1.47 (0.3)1.17 (0.1)0.94 (0.1)< 0.0011.23 (0.4)1.20 (0.3)1.17 (0.3)< 0.001
Hematocrit43 (4.5)42 (4.7)43 (4.4)43 (4.3)< 0.001
Blood urea nitrogen (mg/dl)18 (6.5)22 (7.6)18 (5.1)15 (4.7)< 0.001211918< 0.001
Predicted GFR (ml/min/1.73 m2)70 (19.3)67 (21.6)67 (20.6)71 (18.6)< 0.001
  • legend Data are displayed as mean (SD) or %.

  • legend GFR = glomerular filtration rate; LV = left ventricular; NYHA = New York Heart Association.