Table 2

New York Heart Association Functional Classes and Hemodynamic Variables

Control Group (n = 47)Class I (n = 35)Class II (n = 33)Class III/IV (n = 26)
HR (beats/min)65 ± 2*,†70 ± 2*77 ± 4*98 ± 4
BP (mm Hg)132 ± 2/78 ± 1128 ± 4/75 ± 2130 ± 6/72 ± 3128 ± 7/81 ± 5
LVEF (%)61.7 ± 1.4*,‡54.8 ± 2.7*46.7 ± 2.736.3 ± 3.6
BNP (pg/ml)24.9*,‡,§(13.3–38.3)80.2*,‡(29.3–153.0)232.0*(109.1–294.0)404.5 (280.0–686.0)

BNP = B-type natriuretic peptide; BP = blood pressure; HR = heart rate; LVEF = left ventricular ejection fraction.

  • * p < 0.001 vs. class III/IV.

  • p < 0.05 vs. class II.

  • p < 0.001 vs. class II.

  • § p < 0.001 vs. class I.

  • p < 0.05 vs. class III/IV. Data are expressed as the mean value ± SEM. Results of plasma BNP levels are expressed as the median value (25th to 75th percentile range).