Table 2

Univariate Cox Analysis Showing the Association Between Various Variables and the Risk of Death or Re-Admission During the Six Months of Follow-up in the Derivation Study

VariablesHR95% CIp Value
Age (yrs), per five-year increase1.030.93–1.130.6
Gender (male)0.870.49–1.560.6
Ischemic1.140.65–2.00.6
Diabetes1.160.58–2.320.7
Atrial fibrillation0.610.30–1.260.2
Creatininemia1.020.98–1.060.3
Inotropic use2.341.26–4.340.007
LVEF0.950.78–1.160.6
Doppler mitral pattern
 “Abnormal relaxation” pattern1
 “Pseudo-normal” pattern3.271.43–7.490.005
 “Restrictive” pattern6.302.78–14.250.0001
Serial BNP
BNP admission, per 100 ng/l increase1.061.03–1.100.0001
 BNP day 2, per 100 ng/l increase1.071.03–1.110.0001
 BNP predischarge, per 100 ng/l increase1.221.15–1.300.0001
 Percentage decrease BNP, per 10% decrease0.840.77–0.900.0001
BNP predischarge (per quartile of distribution)
 First quartile (0–130)1
 Second quartile (130–370)2.940.92–9.370.07
 Third quartile (370–660)4.421.45–13.450.009
 Fourth quartile (660–1,725)13.774.71–40.230.0001
Percentage decrease BNP (per quartile of distribution)
 First quartile (<38%)1
 Second quartile (38%–63%)0.940.49–1.810.85
 Third quartile (63%–79%)0.400.19–0.870.02
 Fourth quartile (>79%)0.180.07–0.480.001

BNP = B-type natriuretic peptide; CI = confidence interval; HR = hazard ratio; LVEF = left ventricular ejection fraction; Percentage decrease BNP = (BNP admission − predischarge BNP)/BNP admission.