Table 2

Bivariate Relations of Clinical Variables to Aortic Valve Abnormalities

Normal (n = 3,709)Sclerosis/Stenosis (n = 1,405)p Value
A. Continuous Variables
Age (yr)72.0 ± 5.274.7 ± 6.1<0.0001
Height (cm)164.8 ± 9.5165.2 ± 9.7NS
Weight (kg)73 ± 14.671.7 ± 13.8NS
Waist circumference (cm)93.7 ± 13.194.0 ± 12.3NS
Hip circumference (cm)101.9 ± 10.0100.7 ± 8.80.0002
Fibrinogen (mg/dl)319.2 ± 63.7324.0 ± 70.3NS
Factor VII (%)126.4 ± 33.0123.4 ± 36.60.009
Factor VIII (%)121.6 ± 37.1122.9 ± 38.4NS
Cholesterol (mg/dl)214.9 ± 39.0214.3 ± 39.7NS
Triglycerides (mg/dl)141.3 ± 74.3145.9 ± 89.0NS
HDL (mg/dl)54.5 ± 15.852.3 ± 15.4<0.0001
LDL (mg/dl)132.8 ± 35.6133.9 ± 35.9NS
Lp(a) (mg/dl)50.7 ± 48.562.3 ± 71.4<0.001
Fasting glucose (mg/dl)109.2 ± 31.7112.5 ± 40.70.007
Fasting insulin (μU/ml)16.4 ± 19.717.8 ± 32.9NS
2-h insulin (μU/ml)86.1 ± 65.079.6 ± 58.40.002
2-h glucose (mg/dl)146.2 ± 56.4150.7 ± 62.5NS
Albumin (g/dl)4.0 ± 0.34.0 ± 0.3NS
Potassium (mEq/liter)4.2 ± 0.44.2 ± 0.4NS
Uric acid (mg/dl)5.6 ± 1.55.8 ± 1.60.0003
Creatinine (mg/dl)1.0 ± 0.31.1 ± 0.4<0.0001
Systolic BP (mm Hg)134.9 ± 21.2138.0 ± 22.1<0.0001
Diastolic BP (mm Hg)70.3 ± 11.369.7 ± 12.0NS
B. Categoric Variables
Smoking
 Never1,707 (47%)608 (44%)NS
 Past1,526 (42%)607 (44%)
 Present422 (12%)162 (12%)
Hypertensiona
 No2,068 (57%)710 (52%)0.001
 Yes1,584 (43%)668 (48%)
Diabetesa
 No3,301 (90%)1,241 (89%)NS
 Yes382 (10%)148 (11%)
Estrogen useb
 No1,928 (86%)607 (90%)NS (0.016)
 Yes300 (14%)67 (10%)
Coronary heart diseasec
 No2,838 (77%)987 (70%)<0.0001
 Yes871 (23%)418 (30%)
  • a Self-reported.

  • b Among women (n = 2,943) only.

  • c Coronary heart disease was defined by physician diagnosis of myocardial infarction, angina, angioplasty, coronary artery bypass grafting or by silent myocardial infarction on electrocardiography. Data are expressed as mean value ± SD or number (%) of subjects. BP = blood pressure; HDL = high density lipoprotein; LDL = low density lipoprotein; Lp(a) = lipoprotein(a).