Table 2

Effect of Statin Therapy on Cardiac Death and ICD Therapy for Ventricular Tachyarrhythmias

Cardiac Death or ICD Therapy for VT/VF Hazard Ratio(95% CI)ICD Therapy for VT/VF Hazard Ratio(95% CI)
Statin0.65 (0.49, 0.87)0.72 (0.52, 0.99)
p Value0.0040.046
  • Time-dependent statin use, using a time-delay of zero days (see Methods). The variables evaluated in the proportional hazards regression stepwise selection model were age ≥65 yrs, congestive heart failure New York Heart Association (NYHA) function class ≥2, blood urea nitrogen (BUN) >25 mg/dl, coronary angioplasty, heart rate ≥80 beats/min, dual chamber implantable cardioverter-defibrillator (ICD), ejection fraction (EF) <0.25, beta-blocker use, diuretic use, coronary artery bypass graft, atrial fibrillation, and QRS duration >0.12 s.

  • This hazard ratio is adjusted for BUN >25 mg/dl, congestive heart failure NYHA functional class ≥2, and beta-blocker use, the only three variables that made a significant contribution to the combined end point model. There were eight missing observations in this model due to missing information about BUN in one patient and NYHA functional class in seven patients. Analyses are based on 153 ventricular tachycardia/ventricular fibrillation (VT/VF) events and 42 cardiac death events not preceded by VT/VF events.