Table 1

Endocrine Differences Among Renin-Angiotensin-Aldosterone System Blockers

ACE InhibitorsARBsRenin Inhibitors
Enzymes
 Plasma renin activityIncreasedIncreasedInhibited
 Plasma renin concentrationIncreasedIncreasedIncreased
 Plasma ACE/tissue ACEInhibitedNot inhibitedNot inhibited
Substrate concentrations
 AngiotensinogenDecreasedDecreasedNo change
 Ang IIncreasedIncreasedDecreased
 BradykininIncreasedNo changeNo change
End products
 Ang IIDecreasedIncreasedDecreased
 Non–ACE-dependent Ang IIPresentBlockedBlocked
 Ang III, Ang IVDecreasedIncreasedDecreased
 Ang(1–7)IncreasedIncreasedDecreased
 AldosteroneDecreasedDecreasedDecreased

ACE = angiotensin-converting enzyme; Ang = angiotensin; ARB = angiotensin receptor blocker.