Table 1

Baseline Characteristics

Baseline VariableNo Anemia (n = 5,101)Anemia (n = 1,058)p Value
Clinical data
 Age (yrs)65 ± 1469 ± 14<0.0001
 Gender (% male)67640.046
 Race (% Caucasian)82790.007
 Heart rate (beats/min)74 ± 1375 ± 130.10
 Body mass index (kg/m2)30 ± 729 ± 70.23
 Systolic blood pressure (mm Hg)120 ± 23117 ± 240.037
 Diabetes mellitus (%)2535<0.0001
 Hypertension (%)43390.019
 Myocardial infarction (%)43440.36
 Mortality rate (%)2647<0.0001
Laboratory data
 Hemoglobin (g/dl)13.9 ± 1.410.4 ± 1.1<0.0001
 Mean corpuscular volume (fl)90 ± 688 ± 8<0.0001
 B-type natriuretic peptide (pg/ml)529 ± 702962 ± 1,007<0.0001
 Blood urea nitrogen (mg/dl)24 ± 1438 ± 24<0.0001
 Total cholesterol (mg/dl)183 ± 51154 ± 45<0.0001
 Low-density lipoprotein cholesterol (mg/dl)105 ± 4084 ± 33<0.0001
 Triglycerides (mg/dl)171 ± 166148 ± 1410.0005
 Sodium (mEq/l)140 ± 13139 ± 14<0.0001
 Serum creatinine (mg/dl)1.20 ± 0.741.79 ± 1.36<0.0001
 Estimated GFR (ml/min/1.73 m2)72 ± 2757 ± 36<0.0001
Medications
 Iron supplementation (%)721<0.0001
 Erythropoiesis stimulating agents (%)18<0.0001
 ACE inhibitor/ARB (%)72/2165/21<0.0001
 Beta-blocker (%)7769<0.0001
 Calcium channel blocker (%)22240.032
 Digitalis (%)3930<0.0001
 Nitrates (%)3744<0.0001
 Statin (%)55520.072
 Loop diuretic (%)8086<0.0001
 Thiazide diuretic (%)1824<0.0001
Echocardiographic data
 LV ejection fraction (%-U)34 ± 1735 ± 170.025
 LV end-diastolic diameter (cm)6.4 ± 1.06.4 ± 1.20.080
 LA area (cm2)27 ± 929 ± 9<0.0001
 Estimated LV mass (g)281 ± 105281 ± 1020.93
 LV wall motion score1.8 ± 0.61.8 ± 0.60.69
 Diastolic stage ≥II (%)4660<0.0001
 MR severity ≥3+ (%)17200.010
 RV systolic pressure (mm Hg)39 ± 1443 ± 14<0.0001
 TR severity ≥3+ (%)1020<0.0001

ACE = angiotensin-converting enzyme; ARB = angiotensin receptor blocker; GFR = glomerular filtration rate; LA = left atrial; LV = left ventricular; MR = mitral regurgitation; RV = right ventricular; TR = tricuspid regurgitation.