Table 1

Baseline Characteristics

CharacteristicUltrafiltration (n = 100)Standard Care (n = 100)p Value
Age (yrs)
 Mean ± SD62 ± 1563 ± 140.823
 Range27–8623–88
Male gender (%)70 (70)68 (68)0.879
Race
 Caucasian (%)55 (55.0)52 (52.0)
 African American (%)41 (41.0)40 (40.0)0.489
Comorbidities
 History of hypertension (%)74 (74.0)74 (74.0)1.000
 Coronary artery disease (%)56 (56.0)48 (48.0)0.474
 Chronic obstructive pulmonary disease (%)27 (27.0)30 (30.0)0.755
 Diabetes (%)50 (50.0)50 (49.0)0.887
Heart failure characteristics
 Prior heart failure (%)95 (95.0)95 (95.0)1.000
 Hospitalizations for heart failure in ≤12 monthsn = 89n = 90
  Mean ± SD1.6 ± 1.91.5 ± 1.70.981
  Range0–100–10
 Left ventricular ejection fraction ≤40% (%)71 (71.0)70 (70.0)0.736
 Third heart sound (%)44 (44.0)32 (32.0)0.109
 Jugular venous distension >10 cm (%)68 (68.0)62 (62.0)0.363
 Pulmonary rales (%)59 (59.8)51 (51.3)0.343
 Peripheral edema (%)81 (81.0)79 (79.0)0.860
 New York Heart Association functional class
  Mean ± SD3.4 ± 0.63.4 ± 0.60.861
  Range2–42–4
  III (%)52 (52)48 (48)
  IV (%)45 (45)45 (45)
 Minnesota Living with Heart Failure scoren = 81n = 72
  Mean ± SD70 ± 2374 ± 180.707
  Range4–10536–105
Vital signs
 Weight (kg)n = 100n = 99
  Mean ± SD101 ± 2796 ± 290.194
  Range51–19851–210
 Systolic blood pressure (mm Hg)n = 100n = 100
  Mean ± SD126 ± 26129 ± 240.233
  Range80–22190–214
 Heart rate (beats/min)n = 100n = 100
  Mean ± SD81 ± 1783 ± 160.381
  Range50–13444–131
Laboratory measurements
 Blood urea nitrogen (mg/dl)n = 99n = 100
  Mean ± SD32 ± 1633 ± 200.920
  Range7–858–102
 Serum creatinine (mg/dl)n = 99n = 100
  Mean ± SD1.5 ± 0.51.5 ± 0.50.834
  Range0.7–2.80.5–2.7
 Serum sodium (mg/dl)n = 100n = 100
  Mean ± SD139 ± 5139 ± 50.751
  Range125–147121–151
 Serum potassium (mg/dl)n = 99n = 100
  Mean ± SD4.0 ± 0.64.2 ± 0.60.028
  Range2.0–5.93.0–6.3
 B-type natriuretic peptide level (pg/ml)n = 71n = 81
  Mean ± SD1,256 ± 1,2031,309 ± 1,4940.840
  Range8–5,0005–9,791
 Hematocrit (%)n = 99n = 100
  Mean ± SD36 ± 536 ± 60.643
  Range25–4712–51
Medications
 Angiotensin-converting enzyme inhibitors (%)49 (49.0)49 (49.0)1.000
 Angiotensin receptor blockers (%)14 (14.0)19 (19.0)0.446
 Beta-blockers (%)65 (65.0)66 (66.0)1.000
 Calcium channel blockers (%)8 (8.0)8 (8.0)1.000
 Aldosterone antagonists (%)21 (21.0)22 (22.0)0.864
 Loop diuretics (%)72 (72.0)77 (77.0)0.517
 Furosemide-equivalent diuretic dose (mg)n = 72n = 77
  Mean ± SD129 ± 122119 ± 1160.559
  Range20–80020–800
  • 1 mg bumetamide = 10 mg torsemide = 20 mg furosemide.