Table 2

Heart Failure Hospitalization and Mortality by Diabetic Drug Category

Heart Failure HospitalizationDeath
TZD (n = 818)No Insulin-Sensitizing Medication (n = 4,700)TZD (n = 818)No Insulin-Sensitizing Medication (n = 4,700)
2-yr outcome (%)134 (16.4)741 (15.8)168 (20.5)1,192 (25.4)
Unadjusted hazard ratio (95% CI)1.03 (0.85–1.23)1.00.78 (0.67–0.92)1.0
Age-adjusted hazard ratio (95% CI)1.01 (0.84–1.21)1.00.85 (0.72–1.00)1.0
Fully adjusted hazard ratio (95% CI)1.00 (0.81–1.24)1.00.98 (0.81–1.17)1.0

Hazard ratio compares heart failure hospitalization or death in patients on TZDs versus patients not on TZDs.

CI = confidence interval; TZD = thiazolidinedione.

  • p = 0.79

  • p = 0.003.