Table 2

Hazard Ratios for 1-Year All-Cause Mortality

Hazard Ratio (95% CI)p Value
(A) Univariable
 Age (yrs)1.08 (1.07–1.10)<0.001
 History of heart failure2.82 (1.88–4.22)<0.001
 Previous MI1.24 (0.94–1.64)0.14 (NS)
 Heart rate (per beat/min)1.02 (1.01–1.02)<0.001
 SBP (per mm Hg)0.99 (0.99–0.99)<0.001
 ST-segment depression on ECG1.81 (1.36–2.41)<0.001
 Creatinine (per mg/dl)1.82 (1.47–2.26)<0.001
 Inpatient PCI0.10 (0.03–0.33)<0.001
 hs-CRP (per μg/l)1.12 (1.09–1.14)<0.001
 TnI negative (<0.06 μg/l)1.00
  Q1 (0.07–0.47 μg/l)2.21 (1.32–3.69)0.003
  Q2 (0.48–2.39 μg/l)2.08 (1.24–3.49)0.005
  Q3 (2.40–12.68 μg/l)2.53 (1.53–4.21)<0.001
  Q4 (>12.68 μg/l)2.74 (1.65–4.54)<0.001
 H-FABP
  Q1 (<6.38 μg/l)1.00
  Q2 (6.38–12.39 μg/l)4.45 (2.47–8.00)<0.001
  Q3 (12.39–36.2 μg/l)8.78 (4.99–15.46)<0.001
  Q4 (>36.2 μg/l)11.69 (6.67–20.49)<0.001
(B) TnI multivariable
 Age (per yr)1.07 (1.06–1.09)<0.001
 History of heart failure1.55 (0.96–250)0.073 (NS)
 Previous MI1.11 (0.79–1.55)0.55 (NS)
 Heart rate (per beat/min)1.007 (1.001–1.013)0.028
 SBP (per mm Hg)0.995 (0.990–1.000)0.039
 ST-segment depression on ECG1.37 (0.98–1.93)0.069
 Creatinine (mg/dl)1.36 (1.12–1.66)0.002
 Inpatient PCI0.37 (0.11–1.23)0.11 (NS)
 hs-CRP (per μg/l)1.08 (1.06–1.11)<0.001
 TnI
  Negative (<0.06 μg/l)1.00
  Q1 (0.07–0.47 μg/l)1.56 (0.88–2.76)0.13 (NS)
  Q2 (0.48–2.39 μg/l)1.66 (0.94–2.95)0.081 (NS)
  Q3 (2.40–12.68 μg/l)1.91 (1.09–3.37)0.025
  Q4 (>12.68 μg/l)2.38 (1.35–4.19)0.003
(C) H-FABP multivariable
 Age (per yr)1.06 (1.05–1.08)<0.001
 History of heart failure1.45 (0.90–2.33)0.12 (NS)
 Previous MI1.15 (0.82–1.60)0.43 (NS)
 Heart rate (per beat/min)1.008 (1.002–1.014)0.013
 SBP (per mm Hg)0.995 (0.990–1.000)0.045
 ST-segment depression on ECG1.36 (0.97–1.91)0.076 (NS)
 Creatinine (per mg/dl)1.20 (0.99–1.44)0.061 (NS)
 Inpatient PCI0.40 (0.12–1.33)0.14 (NS)
 hs-CRP (per μg/l)1.08 (1.05–1.10)<0.001
 H-FABP
  Q1 (<6.38 μg/l)1.0
  Q2 (6.38–12.39 μg/l)2.32 (1.25–4.30)0.007
  Q3 (12.39–36.2 μg/l)3.17 (1.73–5.82)<0.001
  Q4 (>36.2 μg/l)4.88 (2.67–8.93)<0.001

(A) Unadjusted for other factors; (B) TnI quartiles adjusted for the GRACE risk factors plus hs-CRP; (C) H-FABP quartiles adjusted for the GRACE risk factors plus hs-CRP with TnI as a continuous variable.

CI = confidence interval; hs-CRP = highly sensitive C-reactive protein; TnI = troponin I; other abbreviations as in Table 1.