Table 1

Patient Demographics (n = 254)

Pretest Probability of Significant CADp Value
>70% High (n = 105)30% to 70% Intermediate (n = 83)<30% Low (n = 66)
Typical angina89 (85)31 (37)3 (4)
Atypical angina16 (15)29 (35)21 (32)<0.0001
Nonanginal chest pain0 (0)23 (28)42 (64)
Men97 (92)47 (57)27 (41)<0.0001
Age (yrs)63 ± 961 ± 850 ± 12<0.0001
BMI (kg/m2)27.5 ± 4.227.1 ± 4.826.7 ± 4.2NS
Heart rate (beats/min)57 ± 860 ± 761 ± 7<0.01
Risk factors
 Hypertension68 (65)43 (52)30 (45)<0.05
 Hypercholesterolemia71 (68)52 (63)14 (21)<0.0001
 Diabetes mellitus§16 (15)11 (13)4 (6)NS
 Current smoker32 (30)16 (19)16 (24)NS
 Previous smoker14 (13)6 (7)4 (6)NS
 Family history of CAD57 (54)39 (47)29 (44)NS
 Obesity32 (30)21 (25)13 (20)NS
Calcium score (Agatston score)#354 (103–814)134 (1–296)0 (0–56)<0.0001
Conventional coronary angiography
 Prevalence of obstructive CAD82 (78)32 (39)12 (18)<0.0001
 Absence of CAD6 (6)21 (25)36 (55)<0.0001
 Nonsignificant disease17 (16)30 (36)18 (27)
 Single-vessel disease42 (40)22 (27)9 (14)
 Multivessel disease40 (38)10 (12)3 (5)
  • Mean and standard deviation.

  • Blood pressure ≥140/90 mm Hg or treatment for hypertension.

  • Total cholesterol >180 mg/dl or treatment for hypercholesterolemia.

  • § Treatment with oral antidiabetic medication or insulin.

  • Family history of coronary artery disease (CAD), having first- or second-degree relatives with premature CAD (age <55 years).

  • Body mass index (BMI) ≥30 kg/m2.

  • # Median and quartiles. Values are n (%) unless otherwise indicated. Categorical variables were tested with chi-square test. Continuous variables were tested with 1-way analysis of variance. If not normally distributed, continuous variables were compared with Kruskal-Wallis test. The p values <0.05 were considered statistically significant.