Table 2

Baseline Pre-Operative and Operative Data as a Function of the Severity of Prosthesis-Patient Mismatch

VariablesNonsignifcant PPM (n = 1,739)Moderate PPM (n = 797)Severe PPM (n = 40)p Value
Pre-operative data
 Age, yrs68 ± 1071 ± 969 ± 11<0.0001
 Female, %335067<0.0001
 BSA, m21.8 ± 0.21.8 ± 0.21.9 ± 0.3<0.0001
 BMI, kg/m226 ± 529 ± 532 ± 7<0.0001
 CAD, %5763750.0003
 NYHA functional class III to IV, %616867<0.0001
 Hypertension, %545968<0.0001
 Diabetes, %182835<0.0001
 Renal failure, %101318<0.0001
 Chronic lung disease, %191915NS
 TIA/stroke, %8610NS
 Predominant AS, %546372<0.0001
 LVEF, %59 ± 1560 ± 1462 ± 13NS
 LVEF <50%, %191718NS
Operative data
 Mechanical prosthesis, %241443<0.0001
 Prosthesis size ≤21 mm, %163880<0.0001
 Concomitant CABG, %434658NS
 CPB time, min116 ± 40117 ± 51132 ± 560.05
 Projected EOAI, cm2/m21.1 ± 0.20.8 ± 0.050.6 ± 0.04<0.0001
Post-operative (1-month) data
 EOAI, cm2/m21.1 ± 0.20.8 ± 0.060.6 ± 0.08<0.0001
 ΔPPeak, mm Hg22 ± 827 ± 937 ± 16<0.0001
 ΔPMean, mm Hg11 ± 415 ± 521 ± 9<0.0001

Data are mean ± SD or percentage of patients.

AS = aortic stenosis; BMI = body mass index; BSA = body surface area; CABG = coronary artery bypass grafting; CAD = coronary artery disease; CPB = cardiopulmonary bypass; ΔPPeak and ΔPMean = peak and mean transprosthetic gradients; EOAI = indexed effective orifice area; LVEF = left ventricular ejection fraction; NS = not significant; NYHA = New York Heart Association; PPM = prosthesis-patient mismatch; TIA = transient ischemic accident.

  • Significant difference with nonsignificant PPM group;

  • significant difference with moderate PPM group.

  • These data were available in a subset of 496 patients.