Table 1

Baseline Characteristics of Patients in the 2 Groups

Testosterone (n = 35)Placebo (n = 35)
Age (yrs), median (interquartile range)71 (67–76)69 (66–74)
Cause of heart failure, CAD/IDC26/928/7
NYHA functional class, II/III18/1720/15
Diabetes911
Dyslipidemia2118
Hypertension1114
Atrial fibrillation1412
Hypogonadism129
Concomitant therapy
 Beta blockers3031
 ACE inhibitors3234
 Diuretics1617
 Aldosterone receptor blockers1614
 Digoxin78
 Antiplatelet agents2122
 Anticoagulants1615
 Statins2926

Hypogonadism was defined as total testosterone <3.5 ng/ml and free testosterone <2.5 pg/ml. No significant differences were found for any of the comparisons shown. Variables are reported as absolute numbers.

ACE = angiotensin-converting enzyme; CAD = coronary artery disease; IDC = idiopathic dilated cardiomyopathy; NYHA = New York Heart Association.