Table 12

Published Studies of Perioperative Statin Use and Outcomes in Noncardiac Surgery

StudyDesignn (Statin/Total)SurgeryAdjusted OR (95% CI)
Perioperative ComplicationsPerioperative Mortality
Lindenauer et al., 2004 (408)Retrospective/administrative77 082/780,591Major noncardiac0.62 (0.58 to 0.67)
Poldermans et al., 2003 (409)Case-control160 Cases, 320 controlsMajor vascular0.22 (0.10 to 0.47)
O'Neil-Callahan et al., 2005 (410)Retrospective526/1163Major vascular0.52 (0.35 to 0.77)
Kertai et al., 2004 (411)Retrospective162/570AAA surgery0.24 (0.10 to 0.70) (Death or MI)
Landesberg et al., 2003 (417)Retrospective502Major vascular0.54 (0.26 to 1.11)
Kennedy et al., 2005 (412)Retrospective/administrative815/2031 SymptomaticCarotid endarterectomy0.55 (0.32 to 0.95) (Stroke or death)0.25 (0.07 to 0.90)
665/1252 AsymptomaticCarotid endarterectomy0.54 (0.13 to 2.24) (Stroke or death)1.34 (0.61 to 2.93)
Ward et al., 2005 (413)Retrospective72/446Infrainguinal vascular surgery0.36 (0.14 to 0.93)
McGirt et al., 2005 (414)Retrospective657/1566Carotid endarterectomy0.35 (0.15 to 0.85) (Stroke)0.20 (0.04 to 0.99)

AAA indicates abdominal aortic aneurysm; CI, confidence interval; MI, myocardial infarction; n, number of patients; and OR, odds ratio.