Table 2

Effects of Intracoronary OPC-18790 on Systolic Function, Ventriculoarterial Coupling and Myocardial Efficiency

Baseline31.25 μg/min62.5 μg/minp Valuea
SV by td (ml)47 ± 449 ± 547 ± 5NS
CI by td (liters/min per m2)2.4 ± 0.12.4 ± 0.22.3 ± 0.2NS
SW (mm Hg/ml)5,168 ± 7005,381 ± 8425,627 ± 725NS
dP/dtmax/EDV (mm Hg·s−1·ml−1)3.5 ± 0.54.2 ± 0.66.1 ± 0.8< 0.005
Ees(mm Hg/ml)0.74 ± 0.110.90 ± 0.161.37 ± 0.33< 0.05
Msw(mm Hg)42 ± 855 ± 847 ± 6NS
PWRmax/EDV2(W/ml2·1,000)2.95 ± 0.763.49 ± 0.913.47 ± 1.16NS
Ees/Earatio0.25 ± 0.050.30 ± 0.060.45 ± 0.12< 0.05
MV̇o22.12 ± 0.122.14 ± 0.132.17 ± 0.12NS
Efficiencyb(%)31.8 ± 2.632.6 ± 2.834.0 ± 2.7NS
  • a By repeated measures analysis of variance.

  • b Myocardial efficiency (stroke work/myocardial oxygen consumption). Data are presented as mean value ± SEM. CI = cardiac index; dP/dtmax/EDV = preload-adjusted peak rate of rise in left ventricular pressure; Ees= end-systolic elastance; Ees/Ea= ratio of end-systolic elastance to arterial elastance; Msw= preload recruitable stroke work; MV̇o2= predicted myocardial oxygen consumption (ml O2/beat per 100 g); PWRmax/EDV2=maximal power index; SV = stroke volume; SW = stroke work; td = thermodilution method.