Table 1

Effects of Intracoronary OPC-18790 on Heart Rate and Vascular Load

Baseline31.25 μg/min62.5 μg/minp Value
HR (beats/min)88 ± 487 ± 486 ± 4NS
mRAP (mm Hg)9 ± 18 ± 17 ± 1a< 0.01
mPAP (mm Hg)32 ± 327 ± 226 ± 30.05
sPAP (mm Hg)43 ± 437 ± 334 ± 4< 0.005
dPAP (mm Hg)23 ± 320 ± 219 ± 30.07
mPAW (mm Hg)21 ± 318 ± 216 ± 2a< 0.05
EDV (ml)177 ± 12173 ± 12NS
mAoP (mm Hg)101 ± 6101 ± 6100 ± 6NS
sAoP (mm Hg)142 ± 9142 ± 9145 ± 10NS
dAoP (mm Hg)78 ± 480 ± 480 ± 4NS
SVR (dynes·s·cm−5)1,802 ± 1611,870 ± 2051,991 ± 235NS
PVR (dynes·s·cm−5)203 ± 22191 ± 32223 ± 45NS
Ea(mm Hg/ml)3.1 ± 0.33.1 ± 0.33.3 ± 0.4NS
  • a p < 0.05 versus 31.25-μg/min dose. Data are presented as mean value ± SEM. dAoP = diastolic aortic pressure; dPAP = diastolic pulmonary artery pressure; Ea= arterial elastance; EDV = end-diastolic volume; HR = heart rate; mAoP = mean aortic pressure; mPAP = mean pulmonary artery pressure; mPAW = mean pulmonary artery wedge pressure; mRAP = mean right atrial pressure; PVR = pulmonary vascular resistance; sAoP = systolic aortic pressure; sPAP = systolic pulmonary artery pressure; SVR = systemic vascular resistance.