Table 1

Outcomes by Baseline Quartiles

Q1 n (%)Q4 n (%)Q1/Q4
RR*95% CI
LVIDd
 Mortality153 (13.2)351 (27.3)0.4420.365–0.534
 M + M245 (21.1)501 (39.0)0.4850.416–0.565
EF
 Mortality202 (13.9)325 (26.4)0.5010.420–0.597
 M + M329 (22.6)495 (40.2)0.5060.440–0.582
LVIDd + EF
 Mortality55 (10.7)155 (30.6)0.3190.234–0.434
 M + M87 (16.9)227 (44.9)0.3230.253–0.414

CI = confidence interval; EF = ejection fraction; LVIDd = left ventricular internal diastolic diameter; M + M = combined mortality and morbidity; n = number of patients with baseline left ventricular measurements who had an event; Q = quartile; RR = risk ratios by Cox regression.

  • * p < 0.0001. LVIDd, EF, and combined quartiles at baseline are compared with outcomes (mortality and M + M) from pooled valsartan and placebo data, using univariate Cox proportional hazards analysis.