Table 1

Subject Characteristics of the Study Groups

ParameterWD (n = 25) Mean ± SDCR (n = 25) Mean ± SDp Value
Clinical characteristics
 Age (yrs)53.4 ± 6.552.7 ± 11.9NS
 Gender (M/F)21/421/4
 Weight (kg)84.8 ± 9.658.9 ± 6.20.0001
 BMI (kg/m2)27.0 ± 2.119.7 ± 1.80.0001
 Body fat (%)26.0 ± 7.39.3 ± 7.40.0001
Serum markers of inflammation
 hsCRP (mg/l)1.9 ± 2.8 (20)0.3 ± 0.3 (22)0.009
 TGF-β1(ng/ml)35.4 ± 7.1 (20)29.4 ± 6.9 (22)0.008
 TNF-α (pg/ml)1.5 ± 1.0 (22)0.8 ± 0.50.002
Resting hemodynamics
 Systolic BP (mm Hg)131 ± 11102 ± 100.0001
 Diastolic BP (mm Hg)83 ± 661 ± 70.0001
 MAP (mm Hg)99 ± 775 ± 80.0001
 HRrest(beats/min)60 ± 956 ± 8NS

Numbers in parentheses are the actual number of data points analyzed for specific parameter.

BMI = body mass index; CR = caloric restriction; Diastolic BP = resting diastolic blood pressure; hsCRP = high-sensitivity C-reactive protein; HRrest= resting heart rate; MAP = mean arterial pressure; Systolic BP = resting systolic blood pressure; TGF-β1= transforming growth factor-β1; TNF-α = tumor necrosis factor-α; WD = western diet.

  • Mann-Whitney test was used for reported p values; otherwise ttest was used.