Table 2

Efficacy of VCDs for Reducing Time to Hemostasis: CLIP Randomized Trial

CLIP Study Diagnostic Arm—ITTStarClose (n = 136)Standard Compression (n = 72)p Value
Procedure success (%)100 (136/136)100 (72/72)NA
Mean time to hemostasis (min)1.5 (± 4.5)15.5 (± 11.4)<0.001
Mean time to ambulation (min)162 (± 104.6)269.3 (± 134.8)<0.001
Major complications (% patient-based)0 (0/136)0 (0/72)
Minor complications (% patient-based)2.2 (3/136)1.4% (1/72)1.000
Mean time to dischargeability (h)3.5 (± 2.1)5.2 (± 2.1)<0.001
CLIP Study Interventional Arm—ITTStarClose (n = 184)Standard Compression (n = 91)p Value
Procedure success (%)98.998.7NA
Mean time to hemostasis (min)8.0 (± 28.2)29.1 (± 35.3)<0.001
Mean time to ambulation (min)411 (± 297.3)466 (± 257.2)<0.137
Major complications (% patient-based)1.1 (2/184)1.1 (1/91)1.000
Minor complications (% patient-based)4.3 (8/184)9.9 (9/91)0.107

ITT = intention to treat; VCD = vascular closure device.