Table 3

Selected Studies of VCDs as Compared With Manual Compression for Patients Undergoing PCI

StudyStudy TypenDevice ComparisonEnd PointOutcomes
Cura et al. (28)Registry2,918VCD vs. MCVascular complication
  • Angio-Seal 2.9%

  • Perclose 3.2%

  • MC 3.1%

  • p = NS

Dangas et al. (30)Registry5,093VCD vs. MCSurgical repair
  • VCD 2.5%

  • MC 1.5%

  • p = 0.03

Resnic et al. (17)Registry3,027VCD vs. MCVascular complication
  • MC 5.5%

  • VCD 3.0%

  • p = 0.002

Dangas et al. (22)Pooled randomized trials2,095VCD vs. MCDevice complications
  • VCD 8.5%

  • MC 5.9%

  • p = 0.02

Tavris et al. (4)ACC-NCDR166,680VCD vs. MCVascular complication
  • 1.05% to 1.48% VCD

  • 1.70% for MC

  • p < 0.001

Exaire et al. (35)TARGET trial substudy4,736VCD vs. MCTransfusions
  • VCD 1.0%

  • MC 0.8%

  • p = NS

Koreny et al. (16)Meta-analysis4,000VCD vs. MCHematomaRR 1.14 for VCD (0.86–1.51)
Vaitkus et al. (33)Meta-analysis5,045VCD vs. MCVascular complication
  • RR 0.89 for VCD (0.86–0.91)

  • Increased risk for Vasoseal

Nikolsky et al. (29)Meta-analysis37,066VCD vs. MCVascular complication
  • p = 0.06 for Angio-Seal benefit compared with MC

  • Increased risk for Vasoseal

Applegate et al. (7)Registry4,699Angio-Seal vs. MCVascular complication
  • Angio-Seal 1.5%

  • MC 1.7%

  • p = NS

Arora et al. (34)Registry12,937VCD vs. MCVascular complication42% to 58% reduction in vascular complications with VCD vs. MC

ACC-NCDR = American College of Cardiology-National Cardiovascular Data Registry; MC = manual compression; RR = relative risk; other abbreviations as in Table 1.

  • Vascular complication may be defined differently for each study

  • data include both diagnostic and interventional cardiac procedures.