Table 2

Association of Fetuin-A With Continuous Measures of Subclinical CVD: The Rancho Bernardo Study

Fetuin-A Quartiles, Fetuin-A Range (g/l)Fetuin-A Continuous per SD (0.11 g/l) Greater
I <0.45II 0.45–0.51III 0.52–0.58IV ≥0.59
CAC (Ln[CAC + 1])
 n869795104382
 Age- and sex-adjusted1.00 (Ref)−0.33 (−0.95 to 0.30), 0.31−0.32 (−0.95 to 0.31), 0.32−0.63 (−1.25 to −0.02), 0.04−0.24 (−0.45 to −0.02), 0.03
 Lifestyle-adjusted*1.00 (Ref)−0.32 (−0.95 to 0.31), 0.32−0.31 (−0.95 to 0.32), 0.33−0.58 (−1.21 to 0.04), 0.07−0.21 (−0.44 to 0.01), 0.06
 Fully adjusted1.00 (Ref)−0.40 (−1.03 to 0.22), 0.21−0.44 (−1.07 to 0.20), 0.18−0.80 (−1.44 to −0.16), 0.01−0.31 (−0.54 to −0.08), 0.008
Ankle brachial index
 n2802702502451,045
 Age- and sex-adjusted1.00 (Ref)0.01 (−0.01 to 0.04), 0.360.03 (0.01 to 0.04), 0.020.01 (−0.01 to 0.04), 0.340.01 (−0.002 to 0.02), 0.15
 Lifestyle-adjusted*1.00 (Ref)0.01 (−0.01 to 0.03), 0.460.03 (0.002 to 0.05), 0.040.01 (−0.01 to 0.04), 0.390.01 (−0.003 to 0.02), 0.16
 Fully adjusted1.00 (Ref)0.01 (−0.01 to 0.04), 0.440.03 (0.002 to 0.05), 0.030.02 (−0.01 to 0.04), 0.160.01 (0.000 to 0.02), 0.04
Common cIMT (ln[common cIMT])
 n131150148168597
 Age- and sex-adjusted1.00 (Ref)−0.02 (−0.06 to 0.02), 0.30−0.01 (−0.05 to 0.04), 0.790.03 (−0.01 to 0.07), 0.200.01 (−0.002 to 0.03), 0.10
 Lifestyle-adjusted*1.00 (Ref)−0.02 (−0.06 to 0.02), 0.37−0.01 (−0.05 to 0.04), 0.820.03 (−0.01 to 0.07), 0.200.01 (−0.003 to 0.03), 0.11
 Fully adjusted1.00 (Ref)−0.03 (−0.07 to 0.02), 0.25−0.01 (−0.06 to 0.03), 0.510.01 (−0.03 to 0.06), 0.530.01 (−0.01 to 0.02), 0.36
Internal cIMT (ln[internal cIMT])
 n125149143166583
 Age- and sex-adjusted1.00 (Ref)−0.004 (−0.11 to 0.10), 0.940.04 (−0.07 to 0.14), 0.470.06 (−0.04 to 0.17), 0.230.02 (−0.02 to 0.06), 0.26
 Lifestyle-adjusted*1.00 (Ref)0.01 (−0.10 to 0.11), 0.890.04 (−0.06 to 0.15), 0.410.07 (−0.03 to 0.18), 0.190.02 (−0.01 to 0.06), 0.21
 Fully adjusted1.00 (Ref)−0.004 (−0.11 to 0.10), 0.950.02 (−0.09 to 0.13), 0.710.02 (−0.09 to 0.12), 0.750.001 (−0.04 to 0.04), 0.95

Values are beta (95% confidence interval), p value.

CAC = coronary artery calcification; cIMT = carotid intima media thickness; CVD = cardiovascular disease.

  • * Adjusted for age, sex, current smoking, alcohol use, regular physical exercise, and oral estrogen use.

  • Adjusted for lifestyle model (*) plus diabetes, body mass index, total cholesterol, triglycerides, and estimated glomerular filtration rate.